PCNA, the maestro of the replication fork

被引：1422
作者：
Moldovan, George-Lucian
Pfander, Boris
Jentsch, Stefan
机构：
[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
[3] Canc Res UK, Clare Hall Labs, S Mimms EH6 3LD, Herts, England
来源：
CELL | 2007年 / 129卷 / 04期
关键词：
D O I：
10.1016/j.cell.2007.05.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.
引用
收藏
页码：665 / 679
页数：15
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