PCNA, the maestro of the replication fork

被引：1422
作者：
Moldovan, George-Lucian
Pfander, Boris
Jentsch, Stefan
机构：
[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
[3] Canc Res UK, Clare Hall Labs, S Mimms EH6 3LD, Herts, England
来源：
CELL | 2007年 / 129卷 / 04期
关键词：
D O I：
10.1016/j.cell.2007.05.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.
引用
收藏
页码：665 / 679
页数：15
相关论文
共 105 条
[1]   A role for PCNA ubiquitination in immunoglobulin hypermutation [J].
Arakawa, Hiroshi ;
Moldovan, George-Lucian ;
Saribasak, Huseyin ;
Saribasak, Nesibe Nur ;
Jentsch, Stefan ;
Buerstedde, Jean-Marie .
PLOS BIOLOGY, 2006, 4 (11) :1947-1956
[2]   PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication [J].
Arias, EE ;
Walter, JC .
NATURE CELL BIOLOGY, 2006, 8 (01) :84-U33
[3]   Interaction of CR6 (GADD45γ) with proliferating cell nuclear antigen impedes negative growth control [J].
Azam, N ;
Vairapandi, M ;
Zhang, W ;
Hoffman, B ;
Liebermann, DA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) :2766-2774
[4]   L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes [J].
Banks, Damon ;
Wu, Min ;
Higa, Leigh Ann ;
Gavrilova, Nadia ;
Quan, Junmin ;
Ye, Tao ;
Kobayashi, Ryuji ;
Sun, Hong ;
Zhang, Hui .
CELL CYCLE, 2006, 5 (15) :1719-1729
[5]   Regulation of alternative replication bypass pathways at stalled replication forks and its effects on genome stability: a yeast model [J].
Barbour, L ;
Xiao, W .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2003, 532 (1-2) :137-155
[6]   DNA replication in eukaryotic cells [J].
Bell, SP ;
Dutta, A .
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :333-374
[7]   Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].
Bienko, M ;
Green, CM ;
Crosetto, N ;
Rudolf, F ;
Zapart, G ;
Coull, B ;
Kannouche, P ;
Wider, G ;
Peter, M ;
Lehmann, AR ;
Hofmann, K ;
Dikic, I .
SCIENCE, 2005, 310 (5755) :1821-1824
[8]   DNA methylation patterns and epigenetic memory [J].
Bird, A .
GENES & DEVELOPMENT, 2002, 16 (01) :6-21
[9]   Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex [J].
Bowman, GD ;
O'Donnell, M ;
Kuriyan, J .
NATURE, 2004, 429 (6993) :724-730
[10]   Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1 [J].
Bruning, JB ;
Shamoo, Y .
STRUCTURE, 2004, 12 (12) :2209-2219
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