What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons

被引：183

作者：

Babiloni, Claudio ^{[1
,2
]}

Blinowska, Katarzyna ^{[3
,4
]}

Bonanni, Laura ^{[5
,6
]}

Cichocki, Andrej ^{[7
,8
,9
]}

De Haan, Willem ^{[10
]}

Del Percio, Claudio ^{[1
]}

Dubois, Bruno ^{[11
,12
]}

Escudero, Javier ^{[13
]}

Fernandez, Alberto ^{[14
,15
]}

Frisoni, Giovanni ^{[16
,17
,18
,19
]}

Guntekin, Bahar ^{[20
]}

Hajos, Mihaly ^{[21
]}

Hampel, Harald ^{[11
,12
,22
]}

Ifeachor, Emmanuel ^{[23
]}

Kilborn, Kerry ^{[24
]}

Kumar, Sanjeev ^{[25
]}

Johnsen, Kristinn ^{[26
]}

Johannsson, Magnus ^{[26
]}

Jeong, Jaeseung ^{[27
]}

LeBeau, Fiona ^{[28
]}

Lizio, Roberta ^{[29
]}

da Silva, Fernando Lopes ^{[30
]}

Maestu, Fernando ^{[14
,15
]}

McGeown, William J. ^{[31
]}

McKeith, Ian ^{[28
]}

Moretti, Davide Vito ^{[16
]}

Nobili, Flavio ^{[32
,33
]}

Olichney, John ^{[34
]}

Onofrj, Marco ^{[5
,6
]}

Palop, Jorge J. ^{[35
]}

Rowan, Michael ^{[36
]}

Stocchi, Fabrizio ^{[37
]}

Struzik, Zbigniew M. ^{[38
,39
,40
,41
]}

Tanila, Heikki ^{[42
]}

Teipel, Stefan ^{[43
,44
]}

Taylor, John Paul ^{[28
]}

Weiergraeber, Marco ^{[45
]}

Yener, Gorsev ^{[46
,47
]}

Young-Pearse, Tracy ^{[48
,49
]}

Drinkenburg, Wilhelmus H. ^{[50
]}

Randall, Fiona ^{[51
]}

机构：

[1] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy

[2] Hosp San Raffaele Cassino, Cassino, FR, Italy

[3] Univ Warsaw, Fac Phys, Warsaw, Poland

[4] Nalecz Inst Biocybernet, Warsaw, Poland

[5] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[6] Univ G dAnnunzio, CESI, Chieti, Italy

[7] Skolkovo Inst Sci & Technol SKOLTECH, Moscow, Russia

[8] PAS, Syst Res Inst, Warsaw, Poland

[9] Nicolaus Copernicus Univ UMK, Torun, Poland

[10] Vrije Univ Amsterdam, Amsterdam UMC, Dept Neurol, Amsterdam Neurosci, Amsterdam, Netherlands

[11] Hop La Pitie Salpetriere, AP HP, Dept Neurol, Inst Memory & Alzheimers Dis IM2A, Blvd Hop, Paris, France

[12] Sorbonne Univ, Inst Cerveau & Moelle Epiniere ICM, INSERM, U1127, Paris, France

[13] Univ Edinburgh, Inst Digital Commun, Sch Engn, Edinburgh, Midlothian, Scotland

[14] Univ Complutense, Ctr Biomed Technol, Lab Cognit & Computat Neurosci, Madrid, Spain

[15] Univ Politecn Madrid, Madrid, Spain

[16] IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy

[17] Univ Hosp, Memory Clin, Geneva, Switzerland

[18] Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland

[19] Univ Geneva, Geneva, Switzerland

[20] Istanbul Medipol Univ, Int Sch Med, Dept Biophys, Istanbul, Turkey

[21] Yale Univ, Sch Med, Dept Comparat Med, Translat Neuropharmacol, New Haven, CT USA

[22] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, GRC 21,APM, Blvd Hop, Paris, France

[23] Plymouth Univ, Fac Sci & Engn, Sch Comp Elect & Math, Plymouth, Devon, England

[24] Univ Glasgow, Sch Psychol, Glasgow, Lanark, Scotland

[25] Ctr Addict & Mental Hlth, Geriatr Psychiat Div, Toronto, ON, Canada

[26] Mentis Cura Ehf, Reykjavik, Iceland

[27] Korea Adv Inst Sci & Technol, Program Brain & Cognit Engn, Dept Bio & Brain Engn, Daejeon, South Korea

[28] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England

[29] IRCCS SDN, Naples, Italy

[30] Univ Amsterdam, Swammerdam Inst Life Sci, Ctr Neurosci, Amsterdam, Netherlands

[31] Univ Strathclyde, Sch Psychol Sci & Hlth, Glasgow, Lanark, Scotland

[32] Univ Genoa, Dept Neurosci DINOGMI, Genoa, Italy

[33] IRCCS Osped Policlin San Martino, Clin Neurol, Genoa, Italy

[34] Univ Calif Davis, Dept Neurol, Ctr Neurosci, Davis, CA USA

[35] Gladstone Inst Neurol Dis, San Francisco, CA USA

[36] Trinity Coll Dublin, Dept Pharmacol & Therapeut, Dublin, Ireland

[37] IRCCS San Raffaele Pisana, Rome, Italy

[38] RIKEN, Brain Sci Inst, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[39] Univ Tokyo, Grad Sch Educ, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[40] RIKEN, Adv Ctr Comp & Commun, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[41] Univ Warsaw, Fac Phys, Pasteur 5, PL-02093 Warsaw, Poland

[42] Univ Eastern Finland, AI Virtanen Inst, Kuopio, Finland

[43] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[44] Univ Rostock, Dept Psychosomat & Psychotherapeut Med, Rostock, Germany

[45] Bundesinst Arzneimittel & Med Prod BfArM, Fed Inst Drugs & Med Devices, Expt Neuropsychopharmacol, Bonn, Germany

[46] Dokuz Eylul Univ, Sch Med, Dept Neurosci, Izmir, Turkey

[47] Dokuz Eylul Univ, Sch Med, Dept Neurol, Izmir, Turkey

[48] Harvard Med Sch, Ann Romney Ctr Neurol Dis, Boston, MA 02115 USA

[49] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[50] Janssen Pharmaceut NV, Janssen Res & Dev, Beerse, Belgium

来源：

NEUROBIOLOGY OF AGING | 2020年 / 85卷

基金：

英国工程与自然科学研究理事会; 欧盟地平线“2020”;

关键词：

The Alzheimer's Association International; Society to Advance Alzheimer's Research and Treatment (ISTAART); Alzheimer's disease (AD); Electroencephalography and magnetoencephalography (EEG and MEG); Resting-state condition; Event-related potentials and magnetic fields; Preclinical and clinical research; MILD COGNITIVE IMPAIRMENT; EVENT-RELATED POTENTIALS; ALTERNATING PATTERN CAP; AMYLOID-BETA; FUNCTIONAL CONNECTIVITY; EPILEPTIFORM ACTIVITY; WORD REPETITION; MOUSE MODEL; SYNAPTIC DYSFUNCTION; QUANTITATIVE EEG;

D O I：

10.1016/j.neurobiolaging.2019.09.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Electrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic (EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in patients with Alzheimer's disease (AD), despite a surge in recent validated evidence. This position paper of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational electrophysiological techniques applied to both experimental animal models of AD and patients, to probe the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as well as brain network dynamics, synchronization, and functional connectivity, reflecting thalamocortical and corticocortical residual capacity. Converging evidence shows relationships between abnormalities in EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting evidence for the application of electrophysiology in AD clinical research as well as drug discovery pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main multicentric projects planned in AD patients, to produce conclusive findings challenging the present regulatory requirements and guidelines for AD studies. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：58 / 73

页数：16

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