Sparfloxacin-metal complexes as antifungal agents - Their synthesis, characterization and antimicrobial activities

被引：36

作者：

Sultana, Najma ^{[1
]}

Arayne, M. Saeed ^{[2
]}

Gul, Somia ^{[1
]}

Shamim, Sana ^{[1
]}

机构：

[1] Univ Karachi, Fac Pharm, Dept Pharmaceut Chem, Res Inst Pharmaceut Sci, Karachi 75270, Pakistan

[2] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2010年 / 975卷 / 1-3期

关键词：

Sparfloxacin; Metal complexes; IR; NMR; Elemental analyses; Antimicrobial activities; CRYSTAL-STRUCTURE; ANTIBACTERIAL ACTIVITY; COPPER(II) COMPLEX; CIPROFLOXACIN; DNA; CU(II); GYRASE; IONS; OFLOXACIN; NI(II);

D O I：

10.1016/j.molstruc.2010.04.038

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Metal complexes with the third-generation quinolone antibacterial agent sparfloxacin (SPFX) or 5-amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8,di-fluoro-1-4-dihydro-4-oxo-3-qunocarboxylic acid have been synthesized and characterized with physicochemical and spectroscopic techniques such as TLC, IR, NMR and elemental analyses. In these complexes, sparfloxacin acts as bidentate deprotonated ligands bound to the metal through the pyridone oxygen and one carboxylate oxygen. The antimicrobial activity of these complexes has been evaluated against four Gram-positive and seven Gram-negative bacteria. Antifungal activity against five different fungi has been evaluated and compared with reference drug sparfloxacin. Fe2+-SPFX and Cd2+-SPFX complexes showed remarkable potency as compared to the parent drug. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：285 / 291

页数：7

共 36 条

[1] EFFECTS OF CIPROFLOXACIN ON PLASMID DNA SUPERCOILING OF ESCHERICHIA-COLI TOPOISOMERASE-I AND GYRASE MUTANTS [J].

ALEIXANDRE, V ;

HERRERA, G ;

URIOS, A ;

BLANCO, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (01) :20-23

[2]

[Anonymous], 1996, Goodman and Gilman's: The Pharmacological Basis of Therapeutics, V9th

[3]

Arayne M. S., 2005, PAK J PHARM SCI, V18, P23

[4] Preparation and spectroscopic characterization of metal complexes of gliquidone [J].

Arayne, M. Saeed ;

Sultana, Najma ;

Mirza, Agha Zeeshan .

JOURNAL OF MOLECULAR STRUCTURE, 2009, 927 (1-3) :54-59

[5]

DYER JR, 1974, APPL ABSORPTION SPEC

[6] Structure, antimicrobial activity and DNA-binding properties of the cobalt(II)-sparfloxacin complex [J].

Efthimiadou, Eleni K. ;

Karaliota, Alexandra ;

Psomas, George .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (14) :4033-4037

[7] Mononuclear dioxomolybdenum(VI) complexes with the quinolones enrofloxacin and sparfloxacin: Synthesis, structure, antibacterial activity and interaction with DNA [J].

Efthimiadou, Eleni K. ;

Karaliota, Alexandra ;

Psomas, George .

POLYHEDRON, 2008, 27 (01) :349-356

[8] Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin [J].

Efthimiadou, Eleni K. ;

Sanakis, Yiannis ;

Raptopoulou, Catherine P. ;

Karaliota, Alexandra ;

Katsaros, Nikos ;

Psomas, George .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (14) :3864-3867

[9] Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones [J].

Foroumadi, A ;

Emami, S ;

Mehni, M ;

Moshafi, MH ;

Shafiee, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (20) :4536-4539

[10] Synthesis and antibacterial activity of N-[5-(chlorobenzylthio)-1,3,4-thiadiazol-2-yl] piperazinyl quinolone derivatives [J].

Foroumadi, Alireza ;

Firoozpour, Loghman ;

Emami, Saeed ;

Mansouri, Shahla ;

Ebrahimabadi, Abdolrasoul H. ;

Asadipour, Ali ;

Amini, Mohsen ;

Saeid-Adel, Nosratollah ;

Shafiee, Abbas .

ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (02) :138-145

← 1 2 3 4 →