A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight

被引:120
作者
Guan, Huaquan [1 ]
Luo, Wenbin [1 ]
Bao, Beihua [2 ,3 ]
Cao, Yudan [2 ,3 ]
Cheng, Fangfang [2 ,3 ]
Yu, Sheng [2 ,3 ]
Fan, Qiaoling [1 ]
Zhang, Li [2 ,3 ]
Wu, Qinan [2 ,3 ]
Shan, Mingqiu [2 ,3 ]
机构
[1] Nanjing Univ Chinese Med, Sch Chinese Med, Nanjing 210023, Peoples R China
[2] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing 210023, Peoples R China
[3] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China
来源
MOLECULES | 2022年 / 27卷 / 10期
基金
中国国家自然科学基金;
关键词
rosmarinic acid; natural product; pharmacokinetics; pharmacology; phytochemistry; ORIGANUM-VULGARE L; CAPILLARY-ZONE-ELECTROPHORESIS; PRESSURIZED LIQUID EXTRACTION; ENZYME-INHIBITORY ACTIVITIES; PRAECOX SUBSP GROSSHEIMII; BIOASSAY-GUIDED ISOLATION; ACUTE LUNG INJURY; CHEMICAL-CONSTITUENTS; PHENOLIC-COMPOUNDS; ANTIOXIDANT ACTIVITY;
D O I
10.3390/molecules27103292
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polyphenolic acids are the widely occurring natural products in almost each herbal plant, among which rosmarinic acid (RA, C18H16O8) is well-known, and is present in over 160 species belonging to many families, especially the Lamiaceae. Aside from this herbal ingredient, dozens of its natural derivatives have also been isolated and characterized from many natural plants. In recent years, with the increasing focus on the natural products as alternative treatments, a large number of pharmacological studies have been carried out to demonstrate the various biological activities of RA such as anti-inflammation, anti-oxidation, anti-diabetes, anti-virus, anti-tumor, neuroprotection, hepatoprotection, etc. In addition, investigations concerning its biosynthesis, extraction, analysis, clinical applications, and pharmacokinetics have also been performed. Although many achievements have been made in various research aspects, there still exist some problems or issues to be answered, especially its toxicity and bioavailability. Thus, we hope that in the case of natural products, the present review can not only provide a comprehensive understanding on RA covering its miscellaneous research fields, but also highlight some of the present issues and future perspectives worth investigating later, in order to help us utilize this polyphenolic acid more efficiently, widely, and safely.
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页数:28
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