Potential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis

被引：11

作者：

Yu, Yun ^{[1
]}

Liu, Liang ^{[1
]}

Hu, Long-Long ^{[1
]}

Yu, Ling-Ling ^{[2
]}

Li, Jun-Pei ^{[1
]}

Rao, Jing-an ^{[1
]}

Zhu, Ling-Juan ^{[1
]}

Liang, Qian ^{[1
]}

Zhang, Rong-Wei ^{[3
]}

Bao, Hui-Hui ^{[1
]}

Cheng, Xiao-Shu ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China

[2] Nanchang Univ, Affiliated Hosp 2, Dept Rehabil, Nanchang, Jiangxi, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 2, Dept Rheumatol, Nanchang, Jiangxi, Peoples R China

来源：

BIOENGINEERED | 2021年 / 12卷 / 01期

关键词：

Systemic lupus erythematosus; bioinformatics; differentially expressed genes; tissue-specific gene expression; biomarkers; CHEMOKINE RECEPTORS; AUTOIMMUNE-DISEASE; DENDRITIC CELLS; GELATINASE-B; BONE-MARROW; SIGNATURE; MATRIX-METALLOPROTEINASE-9; ATHEROSCLEROSIS; MANIFESTATIONS; MODEL;

D O I：

10.1080/21655979.2021.1939637

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs. However, the underlying etiology and mechanisms remain unclear. This study was performed to identify potential therapeutic targets for SLE using bioinformatics methods. First, 584 differentially expressed genes were identified based on the GSE61635 dataset. Tissue-specific analyses, enrichment analyses, and Protein-Protein interaction network were successively conducted. Furthermore, ELISA was performed to confirm the expression levels of key genes in the control and SLE blood samples. The findings revealed that tissue-specific expression of markers of the hematological system (25.5%, 28/110) varied significantly. CCL2, MMP9, and RSAD2 expression was markedly increased in the SLE samples compared with controls. In conclusion, the identified key genes (CCL2, MMP9, and RSAD2) may act as possible therapeutic targets for the treatment of SLE.

引用

页码：2810 / 2819

页数：10

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