Evaluation of clinical target volume expansion required for involved site neck radiotherapy for lymphoma to account for the absence of a pre-chemotherapy PET-CT in the radiotherapy treatment position

Background and purpose: involved site radiotherapy clinical target volume (CTV) for lymphoma requires an expansion to account for the absence of radiotherapy treatment-position pre-chemotherapy imaging, which is not widely implemented. This prospective imaging study aims to quantify CTV expansion required for neck radiotherapy. Materials and methods: 10 patients from a prospective single centre imaging study underwent a pre chemotherapy FDG-PET-CT in both the diagnostic and radiotherapy treatment position, and subsequently received neck radiotherapy post-chemotherapy. CTVINRT and CTIdiagpET were delineated on the planning CT, following co-registration of the radiotherapy position PET-CT and side-by-side assessment of diagnostic PET-CT respectively. Results: Intra-observer variability was limited, with delineation of CTVINRT highly reproducible and slightly lower for CTVdiagPET (mean DICE 0.88 and 0.8 respectively). Superiorly, CTVdiagPET varied by -10 to +15 mm from CTVINRT. Inferiorly, CTVdiagPET varied by -18 to +6 mm from CTVINRT. Comparing CTVINRT and CTVdiagPET in the axial plane, the mean DICE was 0.74. Mean sensitivity index was 0.75 (range 0.59-0.91), showing that on average 75% of the CTVINRT was encompassed by the CTVdiagPET Conclusions: In the absence of treatment-position PET-CT, CTV expansion cranially and caudally by 10 mm and 18 mm respectively, along with generous contouring in the axial plane, was required to encompass pre-chemotherapy disease. (c) 2017 Elsevier B.V. All rights reserved.