Inflammation, ageing, and bone regeneration

被引：102
作者：
Gibon, Emmanuel [1 ]
Lu, Laura Y. [1 ]
Nathan, Karthik [1 ]
Goodman, Stuart B. [1 ]
机构：
[1] Stanford Univ, Dept Orthopaed Surg, 300 Pasteur Dr,Edwards Bldg R116, Stanford, CA 94305 USA
来源：
JOURNAL OF ORTHOPAEDIC TRANSLATION | 2017年 / 10卷
关键词：
ageing; bone; inflammation; macrophages; stem cells; MESENCHYMAL STEM-CELLS; ALTERNATIVE ACTIVATION; IL-12; PRODUCTION; LIPOXIN A(4); ONCOSTATIN M; MACROPHAGES; MARROW; EXPRESSION; PERIOSTEUM; TISSUE;
D O I：
10.1016/j.jot.2017.04.002
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Bone healing involves complex biological pathways and interactions among various cell types and microenvironments. Among them, the monocyte-macrophage-osteoclast lineage and the mesenchymal stem cell-osteoblast lineage are critical, in addition to an initial inflammatory microenvironment. These cellular interactions induce the necessary inflammatory milieu and provide the cells for bone regeneration and immune modulation. Increasing age is accompanied with a rise in the basal state of inflammation, potentially impairing osteogenesis. The translational potential of this article: Translational research has shown multiple interactions between inflammation, ageing, and bone regeneration. This review presents recent, relevant considerations regarding the effects of inflammation and ageing on bone healing. (C) 2017 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.
引用
收藏
页码：28 / 35
页数：8
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