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Economic evaluation of ezetimibe treatment in combination with statin therapy in the United States
被引:13
|作者:
Davies, Glenn M.
[1
]
Vyas, Ami
[2
,3
]
Baxter, Carl A.
[4
]
机构:
[1] Merck & Co Inc, Kenilworth, NJ USA
[2] Rutgers State Univ, Sch Publ Hlth, Dept Epidemiol, Piscataway, NJ USA
[3] Univ Rhode Isl, Coll Pharm, Dept Pharm Practice, Kingston, RI 02881 USA
[4] MSD Ltd, Hoddesdon, England
关键词:
Ezetimibe;
statins;
coronary heart disease;
cerebrovascular disease;
cost-effectiveness;
HIGH-RISK PATIENTS;
COST-EFFECTIVENESS;
CARDIOVASCULAR-DISEASE;
MYOCARDIAL-INFARCTION;
PRIMARY PREVENTION;
HEART-ASSOCIATION;
CHOLESTEROL;
ADHERENCE;
EFFICACY;
RECOMMENDATIONS;
D O I:
10.1080/13696998.2017.1320559
中图分类号:
F [经济];
学科分类号:
02 ;
摘要:
Aims: This study assessed the cost-effectiveness of ezetimibe with statin therapy vs statin monotherapy from a US payer perspective, assuming the impending patent expiration of ezetimibe. Methods: A Markov-like economic model consisting of 28 distinct health states was used. Model population data were obtained from US linked claims and electronic medical records, with inclusion criteria based on diagnostic guidelines. Inputs came from recent clinical trials, meta-analyses, and cost-effectiveness analyses. The base-case scenario was used to evaluate the cost-effectiveness of adding ezetimibe 10mg to statin in patients aged 35-74 years with a history of coronary heart disease (CHD) and/or stroke, and with low-density lipoprotein cholesterol (LDL-C) levels >= 70mg/dL over a lifetime horizon, assuming a 90% price reduction of ezetimibe after 1 year to take into account the impending patent expiration in the second quarter of 2017. Sub-group analyses included patients with LDL-C levels >= 100mg/dL and patients with diabetes with LDL-C levels >= 70mg/dL. Results: The lifetime discounted incremental cost-effectiveness ratio (ICER) for ezetimibe added to statin was $9,149 per quality-adjusted life year (QALY) for the base-case scenario. For patients with LDL-C levels >= 100mg/dL, the ICER was $839/QALY; for those with diabetes and LDL-C levels >= 70mg/dL, it was $560/QALY. One-way sensitivity analyses showed that the model was sensitive to changes in cost of ezetimibe, rate reduction of non-fatal CHD, and utility weight for non-fatal CHD in the base-case and sub-group analyses. Limitations: Indirect costs or treatment discontinuation estimation were not included. Conclusions: Compared with statin monotherapy, ezetimibe with statin therapy was cost-effective for secondary prevention of CHD and stroke and for primary prevention of these conditions in patients whose LDL-C levels are >= 100mg/dL and in patients with diabetes, taking into account a 90% cost reduction for ezetimibe.
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页码:723 / 731
页数:9
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