Tying the knot: Making of lasso peptides

被引：7

作者：

Bierbaum, Gabriele ^{[1
]}

Jansen, Andrea ^{[1
]}

机构：

[1] Inst Med Microbiol, Inst Immunol, Inst Parasitol, D-53105 Bonn, Germany

来源：

CHEMISTRY & BIOLOGY | 2007年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.chembiol.2007.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Chemistry & Biology, Duquesne and colleagues [1] describe the biosynthetic machinery of microcin J25, an antibacterial peptide that adopts an exceptional three-dimensional structure resembling a knot. The dedicated enzymes, McjB and McjC, were identified and employed to produce this modification in vitro.

引用

页码：734 / 735

页数：2

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