LESIONS OF THE LATERODORSAL TEGMENTAL NUCLEUS ALTER THE CHOLINERGIC INNERVATION AND NEUROPEPTIDE Y EXPRESSION IN THE MEDIAL PREFRONTAL CORTEX AND NUCLEUS ACCUMBENS

被引：9
作者：
Pereira, P. A. [1 ,2 ,3 ]
Vilela, M. [1 ,2 ]
Sousa, S. [1 ,2 ]
Neves, J. [1 ]
Paula-Barbosa, M. M. [1 ]
Madeira, M. D. [1 ,2 ,3 ]
机构：
[1] Univ Porto, Dept Anat, Fac Med, P-4200319 Oporto, Portugal
[2] Univ Porto, Ctr Expt Morphol CME, Fac Med, P-4200319 Oporto, Portugal
[3] Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200450 Oporto, Portugal
来源：
NEUROSCIENCE | 2015年 / 284卷
关键词：
laterodorsal tegmental nucleus; medial prefrontal cortex; nucleus accumbens; acetylcholine; neuropeptide Y; vasoactive intestinal polypeptide; VASOACTIVE INTESTINAL POLYPEPTIDE; CORTICAL PROJECTION PATTERNS; GABAERGIC INTERNEURONS; CEREBRAL-CORTEX; ELECTRICAL SYNAPSES; MESOLIMBIC DOPAMINE; CONTAINING NEURONS; GENE-EXPRESSION; FRONTAL-CORTEX; SUBSTANCE-P;
D O I：
10.1016/j.neuroscience.2014.10.054
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of the ibotenic acid infused into the area of the laterodorsal tegmental nucleus (LDT) of rats on the expression of cortical and accumbal neuropeptides were assessed. The effects of this manipulation were determined in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) by estimating the numerical density of varicosities immunoreactive for vesicular acetylcholine transporter and the total number of NAc neurons immunoreactive for choline acetyltransferase (ChAT) and neuropeptide Y (NPY) as well as the total number of mPFC neurons immunoreactive for NPY and vasoactive intestinal polypeptide (VIP). In LDT-lesioned rats, the density of the cholinergic varicosities was reduced in the ventral divisions of the mPFC and in all divisions of the NAc. In addition, in these rats, the total number of NPY-immunoreactive neurons was reduced in all subregions of the mPFC and in the NAc. Conversely, the total number of VIP-immunoreactive neurons in the mPFC and of ChAT-immunoreactive neurons in the NAc did not differ between LDT- and sham-lesioned rats. These data provide the first direct evidence for a relationship between selective damage of LDT cholinergic neurons and decreased expression of NPY in the mPFC and NAc. They also reveal that different types of cortical and accumbal interneurons respond differently to the cholinergic denervation induced by LDT lesions. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：707 / 718
页数：12
相关论文
共 83 条
[1]   Involvement of the laterodorsal tegmental nucleus in the locomotor response to repeated nicotine administration [J].
Alderson, HL ;
Latimer, MP ;
Winn, P .
NEUROSCIENCE LETTERS, 2005, 380 (03) :335-339
[2]   Nicotinic modulation of cortical circuits [J].
Arroyo, Sergio ;
Bennett, Corbett ;
Hestrin, Shaul .
FRONTIERS IN NEURAL CIRCUITS, 2014, 8
[3]   Calretinin Expression in the Mammalian Neocortex: A Review [J].
Barinka, F. ;
Druga, R. .
PHYSIOLOGICAL RESEARCH, 2010, 59 (05) :665-677
[4]   On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis [J].
Bartus, RT .
EXPERIMENTAL NEUROLOGY, 2000, 163 (02) :495-529
[5]   Co-localization of vasoactive intestinal polypeptide, gamma-aminobutyric acid and choline acetyltransferase in neocortical interneurons of the adult rat [J].
Bayraktar, T ;
Staiger, JF ;
Acsady, L ;
Cozzari, C ;
Freund, TF ;
Zilles, K .
BRAIN RESEARCH, 1997, 757 (02) :209-217
[6]   ENRICHMENT OF CHOLINERGIC SYNAPTIC TERMINALS ON GABAERGIC NEURONS AND COEXISTENCE OF IMMUNOREACTIVE GABA AND CHOLINE-ACETYLTRANSFERASE IN THE SAME SYNAPTIC TERMINALS IN THE STRIATE CORTEX OF THE CAT [J].
BEAULIEU, C ;
SOMOGYI, P .
JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 304 (04) :666-680
[7]   GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder [J].
Benes, FM ;
Berretta, S .
NEUROPSYCHOPHARMACOLOGY, 2001, 25 (01) :1-27
[8]  
BERNARD V, 1992, J NEUROSCI, V12, P3591
[9]  
Blaha CD, 1996, J NEUROSCI, V16, P714
[10]   Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity [J].
Bloem, Bernard ;
Poorthuis, Rogier B. ;
Mansvelder, Huibert D. .
FRONTIERS IN NEURAL CIRCUITS, 2014, 8
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