CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder

被引：143

作者：

Hoffman, Gabriel E. ^{[1
,2
]}

Bendl, Jaroslav ^{[1
,2
,3
]}

Voloudakis, Georgios ^{[1
,2
,3
]}

Montgomery, Kelsey S. ^{[4
]}

Sloofman, Laura ^{[1
,2
,3
]}

Wang, Ying-Chih ^{[2
]}

Shah, Hardik R. ^{[2
]}

Hauberg, Mads E. ^{[1
,2
,3
]}

Johnson, Jessica S. ^{[1
,3
]}

Girdhar, Kiran ^{[1
,2
,3
]}

Song, Lingyun ^{[5
]}

Fullard, John F. ^{[1
,3
]}

Kramer, Robin ^{[6
]}

Hahn, Chang-Gyu ^{[7
]}

Gur, Raquel ^{[8
]}

Marenco, Stefano ^{[6
]}

Lipska, Barbara K. ^{[6
]}

Lewis, David A. ^{[9
]}

Haroutunian, Vahram ^{[10
,11
]}

Hemby, Scott ^{[12
]}

Sullivan, Patrick ^{[13
]}

Akbarian, Schahram ^{[14
]}

Chess, Andrew ^{[2
]}

Buxbaum, Joseph D. ^{[15
,16
]}

Crawford, Greg E. ^{[5
]}

Domenici, Enrico ^{[17
]}

Devlin, Bernie ^{[9
]}

Sieberts, Solveig K. ^{[4
]}

Peters, Mette A. ^{[4
]}

Roussos, Panos ^{[1
,2
,3
,11
,16
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Pamela Sklar Div Psychiat Genom, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[4] Sage Bionetworks, Seattle, WA USA

[5] Duke Univ, Dept Pediat, Div Med Genet, Durham, NC 27706 USA

[6] NIMH, Human Brain Collect Core, NIH, Bethesda, MD 20892 USA

[7] Univ Penn, Dept Psychiat, Neuropsychiat Signaling Program, Perelman Sch Med, Philadelphia, PA 19104 USA

[8] Univ Penn, Dept Psychiat, Perelman Sch Med, Neuropsychiat Sect, Philadelphia, PA 19104 USA

[9] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[10] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA

[11] JJ Peters VA Med Ctr, Psychiat, Bronx, NY 10468 USA

[12] High Point Univ, Fred Wilson Sch Pharm, Dept Basic Pharmaceut Sci, High Point, NC USA

[13] Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA

[14] Icahn Sch Med Mt Sinai, Dept Psychiat, Div Psychiat Epigen, New York, NY 10029 USA

[15] Icahn Sch Med Mt Sinai, Dept Psychiat, Seaver Autism Res & Treatment, New York, NY 10029 USA

[16] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

[17] Univ Trento, Dept Cellular Computat & Integrat Biol CIBIO, Lab Neurogen Biomarkers, Trento, Italy

来源：

SCIENTIFIC DATA | 2019年 / 6卷 / 1期

关键词：

ASSOCIATION; PREVALENCE; MUTATIONS; ACCURATE; PACKAGE;

D O I：

10.1038/s41597-019-0183-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanisms by which risk alleles with small effects lead to schizophrenia and bipolar disorder. In order to fill this gap between genetics and disease phenotype, we have undertaken a multi-cohort genomics study of postmortem brains from controls, individuals with schizophrenia and bipolar disorder. Here we present a public resource of functional genomic data from the dorsolateral prefrontal cortex (DLPFC; Brodmann areas 9 and 46) of 986 individuals from 4 separate brain banks, including 353 diagnosed with schizophrenia and 120 with bipolar disorder. The genomic data include RNA-seq and SNP genotypes on 980 individuals, and ATAC-seq on 269 individuals, of which 264 are a subset of individuals with RNA-seq. We have performed extensive preprocessing and quality control on these data so that the research community can take advantage of this public resource available on the Synapse platform at http://CommonMind.org.

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