Electrical sources of P300 event-related brain potentials revealed by low resolution electromagnetic tomography .1. Effects of normal aging

被引：50
作者：
Anderer, P
Pascual-Marqui, RD
Semlitsch, HV
Saletu, B
机构：
[1] Univ Vienna, Dept Psychiat, Div Pharmacopsychiat & Sleep Res, A-1090 Vienna, Austria
[2] Univ Zurich Hosp, Dept Psychiat, KEY Inst Brain Mind Res, CH-8091 Zurich, Switzerland
来源：
NEUROPSYCHOBIOLOGY | 1998年 / 37卷 / 01期
关键词：
event-related potentials; spatial analysis; source localization; P300; generators; aging;
D O I：
10.1159/000026472
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The P300 event-related potential (ERP) is considered to be closely related to cognitive processes. Previous reports regarding major generators contributing to the scalp-recorded P300 suggested widely distributed multiple sources. Based on ERPs recorded in 172 normal healthy subjects aged between 20 and 88 years in an auditory oddball paradigm, electrical activity in the brain corresponding to N1 and P300 components was localized by means of low resolution electromagnetic tomography (LORETA). The N1 LORETA generators, located in both auditory cortices, did not change over age. On the other hand, the P300 LORETA generators, located predominantly in the frontal neocortex and less pronounced in the posterior parietal cortex, decreased over age both in frontal and parietal source strength.
引用
收藏
页码：20 / 27
页数：8
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