MicroRNAs, macrocontrol: Regulation of miRNA processing

被引：215

作者：

Slezak-Prochazka, Izabella ^{[1
]}

Durmus, Selvi ^{[1
]}

Kroesen, Bart-Jan ^{[1
]}

van den Berg, Anke ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9700 RB Groningen, Netherlands

来源：

RNA | 2010年 / 16卷 / 06期

关键词：

microRNA; miRNA; biogenesis; processing; regulation; RNA-BINDING PROTEIN; EMBRYONIC STEM-CELLS; POSTTRANSCRIPTIONAL REGULATION; NUCLEAR EXPORT; C-ELEGANS; MICROPROCESSOR COMPLEX; MIR-17-92; CLUSTER; LET-7; MICRORNA; PRE-MIRNAS; EXPRESSION;

D O I：

10.1261/rna.1804410

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a set of small, non-protein-coding RNAs that regulate gene expression at the post-transcriptional level. Maturation of miRNAs comprises several regulated steps resulting in similar to 22-nucleotide single-stranded mature miRNAs. Regulation of miRNA expression can occur both at the transcriptional level and at the post-transcriptional level during miRNA processing. Recent studies have elucidated specific aspects of the well-regulated nature of miRNA processing involving various regulatory proteins, editing of miRNA transcripts, and cellular location. In addition, single nucleotide polymorphisms in miRNA genes can also affect the processing efficiency of primary miRNA transcripts. In this review we present an overview of the currently known regulatory pathways of miRNA processing and provide a basis to understand how aberrant miRNA processing may arise and may be involved in pathophysiological conditions such as cancer.

引用

页码：1087 / 1095

页数：9

共 89 条

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