Maternal use of bupropion and risk for congenital heart defects

被引：65
作者：
Alwan, Sura [2 ]
Reefhuis, Jennita [1 ]
Botto, Lorenzo D. [3 ]
Rasmussen, Sonja A. [1 ]
Correa, Adolfo [1 ]
Friedman, Jan M. [2 ]
机构：
[1] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA
[2] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada
[3] Univ Utah, Div Med Genet, Dept Pediat, Salt Lake City, UT USA
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 01期
关键词：
birth defects; bupropion exposure; congenital heart defects; pregnancy; SEROTONIN-REUPTAKE INHIBITORS; BIRTH-DEFECTS; SMOKING-CESSATION; PREGNANCY; MALFORMATIONS; 1ST-TRIMESTER; PREVALENCE; PAROXETINE; ANOMALIES; WOMEN;
D O I：
10.1016/j.ajog.2010.02.015
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: We sought to determine if maternal bupropion treatment in early pregnancy is associated with congenital heart defects in the infant. STUDY DESIGN: We conducted a retrospective case-control study of birth defects risk factors. Data on 6853 infants with major heart defects were compared with 5869 control infants born in 1997-2004. Bupropion exposure was defined as any reported use between 1 month before and 3 months after conception. RESULTS: Mothers of infants with left outflow tract heart defects were more likely to have reported taking bupropion than mothers of control infants (adjusted odds ratio, 2.6; 95% confidence interval, 1.2-5.7; P = .01). CONCLUSION: We identified a positive association between early pregnancy bupropion use and left outflow tract heart defects; however, the magnitude of the observed increased risk was small. Nevertheless, further studies are needed to confirm these results.
引用
收藏
页码：52.e1 / 52.e6
页数：6
相关论文
共 50 条
  • [21] Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring
    Jin, Xi
    Tian, Xiaoxian
    Liu, Zhen
    Hu, Hui
    Li, Xiaohong
    Deng, Ying
    Li, Nana
    Zhu, Jun
    REPRODUCTIVE TOXICOLOGY, 2016, 59 : 109 - 116
  • [22] Prenatal screening of congenital heart defects in population at low risk of congenital defects. A reality today
    Sainz, J. A.
    Zurita, M. J.
    Guillen, I.
    Borrero, C.
    Garcia-Mejido, J.
    Almeida, C.
    Turmo, E.
    Garrido, R.
    ANALES DE PEDIATRIA, 2015, 82 (01): : 27 - 34
  • [23] Maternal dietary fat intake and the risk of congenital heart defects in offspring
    Collins, R. Thomas, II
    Yang, Wei
    Carmichael, Suzan L.
    Bolin, Elijah H.
    Nembhard, Wendy N.
    Shaw, Gary M.
    PEDIATRIC RESEARCH, 2020, 88 (05) : 804 - 809
  • [24] Maternal Hypertension During Pregnancy and the Risk of Congenital Heart Defects in Offspring: A Systematic Review and Meta-analysis
    Ramakrishnan, Anushuya
    Lee, Laura J.
    Mitchell, Laura E.
    Agopian, A. J.
    PEDIATRIC CARDIOLOGY, 2015, 36 (07) : 1442 - 1451
  • [25] Association between maternal body mass index and congenital heart defects in infants: A meta-analysis
    Zhu, Yu
    Chen, Yong
    Feng, Yu
    Yu, Di
    Mo, Xuming
    CONGENITAL HEART DISEASE, 2018, 13 (02) : 271 - 281
  • [26] Maternal Smoking and Congenital Heart Defects in the Baltimore-Washington Infant Study
    Alverson, Clinton J.
    Strickland, Matthew J.
    Gilboa, Suzanne M.
    Correa, Adolfo
    PEDIATRICS, 2011, 127 (03) : E647 - E653
  • [27] Maternal Asthma, Asthma Medication Use, and the Risk of Congenital Heart Defects
    Lin, Shao
    Herdt-Losavio, Michele
    Gensburg, Lenore
    Marshall, Elizabeth
    Druschel, Charlotte
    BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2009, 85 (02) : 161 - 168
  • [28] Maternal Body Mass Index and Risk of Congenital Heart Defects in Infants: A Dose-Response Meta-Analysis
    Liu, Xuezhen
    Ding, Guoyong
    Yang, Weili
    Feng, Xia
    Li, Yuejin
    Liu, Huamin
    Zhang, Qianqian
    Ji, Long
    Li, Dong
    BIOMED RESEARCH INTERNATIONAL, 2019, 2019
  • [29] Association between prepregnancy body mass index and congenital heart defects
    Gilboa, Suzanne M.
    Correa, Adolfo
    Botto, Lorenzo D.
    Rasmussen, Sonja A.
    Waller, D. Kim
    Hobbs, Charlotte A.
    Cleves, Mario A.
    Riehle-Colarusso, Tiffany J.
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2010, 202 (01) : 51.e1 - 51.e10
  • [30] Maternal Antihypertensive Medication Use and Congenital Heart Defects Updated Results From the National Birth Defects Prevention Study
    Fisher, Sarah C.
    Van Zutphen, Alissa R.
    Werler, Martha M.
    Lin, Angela E.
    Romitti, Paul A.
    Druschel, Charlotte M.
    Browne, Marilyn L.
    HYPERTENSION, 2017, 69 (05) : 798 - +
12345