Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine

被引：4

作者：

Zyuz'kov, G. N. ^{[1
,2
]}

Udut, E. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Simanina, E. V. ^{[1
]}

Polyakova, T. Yu. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Udut, V. V. ^{[1
,2
]}

Minakova, M. Yu. ^{[1
]}

Dygai, A. M. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Agafonov, V. I. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

机构：

[1] Natl Res Tomsk State Univ, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia

[2] Natl Res Tomsk State Univ, Lab Modeling Phys Proc Biol & Med, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 04期

关键词：

signal transduction; JAK; stem cells; regenerative medicine; alkaloids; POSTHYPOXIC ENCEPHALOPATHY; PROGENITOR CELLS; MECHANISMS; INVOLVEMENT; INHIBITOR; STATS; JNK; Z77;

D O I：

10.1007/s10517-017-3824-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the role of some JAK in the effect of diterpene alkaloid songorine on realization of the growth potential of mesenchymal precursor cells. The participation of JAK1, JAK2, and JAK3 in stimulation of proliferation of the precursor cells was demonstrated. Specific inhibitors of these JAK reduced the yield of fibroblast CFU and the rate of their division. Inhibition of JAK2 against the background of songorine treatment increased the rate of precursor differentiation.

引用

页码：443 / 446

页数：4

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