Cloning and heterologous expression of the Trypanosoma brucei lanosterol synthase gene

被引：21

作者：

Buckner, FS

Nguyen, LN

Joubert, BM

Matsuda, SPT

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Rice Univ, Dept Chem, Houston, TX 77005 USA

[3] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2000年 / 110卷 / 02期

关键词：

Trypanosoma brucei; lanosterol synthase; oxidosqualene cyclase; sterol biosynthesis;

D O I：

10.1016/S0166-6851(00)00267-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：399 / 403

页数：5

共 24 条

[1] Mechanism-based inhibitors and other active-site targeted inhibitors of oxidosqualene cyclase and squalene cyclase [J].

Abe, I ;

Zheng, YF ;

Prestwich, GD .

JOURNAL OF ENZYME INHIBITION, 1998, 13 (06) :385-398

[2] ENZYMATIC CYCLIZATION OF SQUALENE AND OXIDOSQUALENE TO STEROLS AND TRITERPENES [J].

ABE, I ;

ROHMER, M ;

PRESTWICH, GD .

CHEMICAL REVIEWS, 1993, 93 (06) :2189-2206

[3]

Ausubel F.A., 1999, CURRENT PROTOCOLS MO

[4]

BarrettBee K, 1995, ACTA BIOCHIM POL, V42, P465

[5]

Beach D. H., 1989, Leishmaniasis: The current status and new strategies for control. Proceedings of a NATO Advanced Study Institute on leishmaniasis: The first centenary (1885-1985), new strategies for control, Zakinthos, Greece, 20-27 September 1987., P765

[6] Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues [J].