Synthesis and antitumor activity of 4-hydroxycoumarin derivatives

被引：96

作者：

Jung, JC

Lee, JH

Oh, S

Lee, JG

Park, OS ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Nat Sci, Dept Chem, Chengju 361763, Chungbuk, South Korea

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[3] Ewha Womans Univ, Coll Med, Dept Neurosci, Seoul 158710, South Korea

[4] KT&G Cent Res Inst, Taejon 303345, Chungnam, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 22期

关键词：

D O I：

10.1016/j.bmcl.2004.09.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5527 / 5531

页数：5

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