Enzyme-linked immunosorbent assay for ondansetron captured from airborne samples

被引：1

作者：

Hreczuk-Hirst, D ^{[1
]}

Rowell, FJ

Reeve, RN

Cumming, RH

Guest, I

机构：

[1] Univ Sunderland, Sch Hlth Sci, NE Biotechnol Ctr, Sunderland SR 3SD, England

[2] Univ Teesside, Sch Sci & Technol, NE Biotechnol Ctr, Middlesbrough TS1 3BA, Cleveland, England

[3] GlaxoWellcome Operat, Occupat Hlth, Ware SG12 0DJ, Herts, England

来源：

ANALYST | 1998年 / 123卷 / 05期

关键词：

ondansetron; enzyme linked immunosorbent assay; airborne workplace monitoring; health and safety;

D O I：

10.1039/a708204e

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and relatively rapid enzyme-linked immunosorbant assay method for the anti-emetic drug ondansetron has been developed for its quantitation in solution. This has been optimised for use with samples that have been obtained following extraction of filters after the drug's capture from air samples in the workplace. The assay has the sample throughput (40 duplicate samples in 3 h), specificity, sensitivity (LOD of 10.5 ng drug ml(-1)) and precision (RSD < 11%) necessary for its use in determining airborne concentrations of ondansetron in such samples as part of an occupational health and hygiene monitoring programme.

引用

页码：1121 / 1126

页数：6

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