Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

被引：178

作者：

Postema, Merel C. ^{[1
]}

van Rooij, Daan ^{[2
]}

Anagnostou, Evdokia ^{[3
,4
]}

Arango, Celso ^{[5
]}

Auzias, Guillaume ^{[6
]}

Behrmann, Marlene ^{[7
]}

Busatto Filho, Geraldo ^{[8
]}

Calderoni, Sara ^{[9
,10
]}

Calvo, Rosa ^{[11
,12
]}

Daly, Eileen ^{[13
]}

Deruelle, Christine ^{[6
]}

Di Martino, Adriana ^{[14
]}

Dinstein, Ilan ^{[15
]}

Duran, Fabio Luis S. ^{[8
]}

Durston, Sarah ^{[16
]}

Ecker, Christine ^{[17
,18
]}

Ehrlich, Stefan ^{[19
]}

Fair, Damien ^{[20
]}

Fedor, Jennifer ^{[21
]}

Feng, Xin ^{[22
,23
]}

Fitzgerald, Jackie ^{[24
,25
]}

Floris, Dorothea L. ^{[2
]}

Freitag, Christine M. ^{[17
]}

Gallagher, Louise ^{[24
,25
]}

Glahn, David C. ^{[26
,27
,28
]}

Gori, Ilaria ^{[29
]}

Haar, Shlomi ^{[30
]}

Hoekstra, Liesbeth ^{[2
,31
]}

Jahanshad, Neda ^{[21
]}

Jalbrzikowski, Maria ^{[24
]}

Janssen, Joost ^{[5
]}

King, Joseph A. ^{[19
]}

Kong, Xiang Zhen ^{[1
]}

Lazaro, Luisa ^{[11
,12
]}

Lerch, Jason P. ^{[32
,33
]}

Luna, Beatriz ^{[21
]}

Martinho, Mauricio M. ^{[34
]}

McGrath, Jane ^{[24
,25
]}

Medland, Sarah E. ^{[35
]}

Muratori, Filippo ^{[9
,10
]}

Murphy, Clodagh M. ^{[13
,36
]}

Murphy, Declan G. M. ^{[36
,37
]}

O'Hearn, Kirsten ^{[21
]}

Oranje, Bob ^{[16
]}

Parellada, Mara ^{[5
]}

Puig, Olga ^{[11
,12
]}

Retico, Alessandra ^{[29
]}

Rosa, Pedro ^{[8
]}

Rubia, Katya ^{[38
]}

Shook, Devon ^{[16
]}

机构：

[1] Max Planck Inst Psycholinguist, Dept Language & Genet, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Donders Ctr Cognit Neuroimaging,Med Ctr, Nijmegen, Netherlands

[3] Univ Toronto, Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Dept Pediat, Toronto, ON, Canada

[5] Univ Complutense, Gregorio Maranon Gen Univ Hosp, Child & Adolescent Psychiat Dept, IiSGM,Sch Med,CIBERSAM, Madrid, Spain

[6] Aix Marseille Univ, CNRS, Inst Neurosci Timone, UMR 7289, Marseille, France

[7] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA

[8] Univ Sao Paulo, Lab Psychiat Neuroimaging LIM 21, Dept & Inst Psiquiatria, Hosp Clin HCFMUSP,Fac Med, Sao Paulo, SP, Brazil

[9] IRCCS Stella Maris Fdn, Viale Tirreno 331, I-56128 Pisa, Italy

[10] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[11] Univ Barcelona, Dept Child & Adolescent Psychiat, IDIBAPS, CIBERSAM, Barcelona, Spain

[12] Univ Barcelona, Psychol Hosp Clin, Dept Med, CIBERSAM,IDIBAPS,Psychiat Unit,2017SGR881, Barcelona, Spain

[13] Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat Psychol & Neurosci, London, England

[14] NYU Child Study Ctr, Inst Pediat Neurosci, New York, NY USA

[15] Ben Gurion Univ Negev, Dept Psychol, Beer Sheva, Israel

[16] Univ Med Ctr Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands

[17] Goethe Univ Frankfurt Main, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Univ Hosp, Frankfurt, Germany

[18] Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med USC, Imaging Genet Ctr, Marina Del Rey, CA USA

[19] Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Dept Child & Adolescent Psychiat, Fac Med, Dresden, Germany

[20] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA

[21] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[22] Jilin Univ, BioKnow Hlth Informat Lab, Coll Comp Sci & Technol, Changchun 130012, Jilin, Peoples R China

[23] Jilin Univ, Key Lab Symbol Computat & Knowledge Engn, Minist Educ, Changchun 130012, Jilin, Peoples R China

[24] Trinity Coll Dublin, Sch Med, Dept Psychiat, Dublin, Ireland

[25] Trinity Coll Dublin, Inst Neurosci, Dublin, Ireland

[26] Boston Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA

[27] Harvard Med Sch, Boston, MA 02115 USA

[28] Olin Neuropsychiat Res Ctr, Hartford, CT USA

[29] Natl Inst Nucl Phys, Pisa Div, Largo B Pontecorvo 3, I-56124 Pisa, Italy

[30] Imperial Coll London, Dept Bioengn, London, England

[31] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands

[32] Hosp Sick Children, Neurosci & Mental Hlth, Toronto, ON, Canada

[33] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[34] Univ Fed Santa Maria, Dept Neuropsychiat, Santa Maria, RS, Brazil

[35] QIMR Berghofer Med Res Inst, Psychiat Genet, Brisbane, Qld, Australia

[36] South London & Maudsley Fdn NHS Trust, Behav & Dev Psychiat Clin Acad Grp, Behav Genet Clin, Adult Autism Serv, London, England

[37] Kings Coll London, Inst Psychiat Psychol & Neurosci, Sackler Inst Translat Neurodev, London, England

[38] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[39] Univ Toronto, Hosp Sick Children, Diagnost Imaging Res, Toronto, ON, Canada

[40] George Washington Univ, Dept Speech Language & Hearing Sci, Washington, DC USA

[41] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

关键词：

DEFICIT HYPERACTIVITY DISORDER; CEREBRAL ASYMMETRY; WHITE-MATTER; FUNCTIONAL LATERALIZATION; YOUNG-CHILDREN; LIFE-SPAN; LANGUAGE; VOLUME; NETWORKS; VOXEL;

D O I：

10.1038/s41467-019-13005-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = -0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.

引用

页数：12

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