Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambarene, Gabon

被引：54

作者：

Mordmueller, Benjamin ^{[1
,2
]}

Szywon, Katja ^{[1
,2
]}

Greutelaers, Benedikt ^{[1
,2
]}

Esen, Meral ^{[1
,2
]}

Mewono, Ludovic ^{[1
,2
]}

Treut, Carolin ^{[1
,2
]}

Muerbeth, Raymund E. ^{[1
,2
]}

Chilengi, Roma ^{[3
]}

Noor, Ramadhani ^{[3
]}

Kilama, Wen L. ^{[3
]}

Imoukhuede, Egeruan Babatunde ^{[4
,8
]}

Imbault, Nathalie ^{[4
,8
]}

Leroy, Odile ^{[4
,8
]}

Theisen, Michael ^{[5
,6
]}

Jepsen, Soren

Milligan, Paul ^{[7
]}

Fendel, Rolf ^{[1
,2
]}

Kremsner, Peter G. ^{[1
,2
]}

Issifou, Saadou ^{[1
,2
]}

机构：

[1] Univ Tubingen, Inst Trop Med, D-72074 Tubingen, Germany

[2] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon

[3] African Malaria Network Trust, Dar Es Salaam, Tanzania

[4] Univ Klinikum Heidelberg, European Vaccine Initiat EEIG, D-69120 Heidelberg, Germany

[5] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen S, Denmark

[6] Univ Copenhagen, Ctr Med Parasitol, Dept Int Hlth Immunol & Microbiol, DK-2300 Copenhagen S, Denmark

[7] London Sch Hyg & Trop Med, Infect Dis Epidemiol Unit, London WC1E 7HT, England

[8] Statens Serum Inst, European Malaria Vaccine Initiat, DK-2300 Copenhagen S, Denmark

来源：

VACCINE | 2010年 / 28卷 / 41期

关键词：

Malaria vaccine; Phase I clinical trial; Malaria immunity;

D O I：

10.1016/j.vaccine.2010.07.085

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria is still one of the major public health threats in sub-Saharan Africa. An effective vaccine could be a sustainable control measure that can be integrated into existing health infrastructures. The malaria vaccine candidate GMZ2 is a recombinant fusion protein of conserved parts of Plasmodium falciparum Glutamate Rich Protein and Merozoite Surface Protein 3 adjuvanted with aluminium hydroxide. GMZ2 is immunogenic and well tolerated in malaria-naive adults from Germany. To assess safety and immunogenicity in malaria-exposed individuals, 40 adults from Lambarene. Gabon were randomly assigned to receive either 100 p,g GMZ2 or a rabies control vaccine three times in monthly intervals. Both vaccines were well tolerated. One month after a full course of vaccination, GMZ2-vaccinated individuals had 1.4-fold (95% confidence interval: [1.1, 1.7]) higher baseline-corrected anti-GMZ2 antibody levels and more GMZ2-specific memory B-cells compared to the rabies group (p=0.039), despite a high prevalence of GMZ2-specific immune reactivity due to previous intense exposure to P. falciparum. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6698 / 6703

页数：6

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