Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

被引：28

作者：

Kim, Young Choong ^{[1
]}

Lee, Mi Kyeong

Sung, Sang Hyun

Kim, Seung Hyun

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

来源：

FITOTERAPIA | 2007年 / 78卷 / 03期

关键词：

Ulmus davidiana var. japonica; guaianes; 1-hydroxytorilin A; anti inflammatory activity;

D O I：

10.1016/j.fitote.2006.11.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1 beta, 7 beta, 8 beta, 10 beta)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：196 / 199

页数：4

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