Synthesis of a GlcNAcylated arginine building block for the solid phase synthesis of death domain glycopeptide fragments

被引：10

作者：

Wang, Siyao ^{[1
]}

Corcilius, Leo ^{[1
]}

Sharp, Phillip P. ^{[2
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Walter & Eliza Hall Inst Med Res, ACRF Chem Biol Div, 1G Royal Parade, Parkville, Vic 3052, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 11期

基金：

澳大利亚研究理事会;

关键词：

Glycopeptides; Glycosylation; GlcNAcylation; Arginine; SPPS; TRADD; FADD; PROTEIN GLYCOSYLATION; EFFECTOR; LINKAGE; GENERATION;

D O I：

10.1016/j.bmc.2017.03.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein we describe the synthesis of glycopeptide fragments from the death domains of TRADD and FADD bearing the recently discovered N omega-GlcNAc-beta-arginine post-translational modification. TRADD and FADD glycopeptides were accessed through the use of a suitably protected synthetic glycosylamino acid 'cassette' that could be directly incorporated into conventional solid phase peptide synthesis (SPPS) protocols. (C) 2017 Elsevier Ltd. All rights reserved.

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收藏

页码：2895 / 2900

页数：6

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