Forkhead box M1 transcription factor: A novel target for cancer therapy

被引：132

作者：

Wang, Zhiwei ^{[1
]}

Ahmad, Aamir ^{[1
]}

Li, Yiwei ^{[1
]}

Banerjee, Sanjeev ^{[1
]}

Kong, Dejuan ^{[1
]}

Sarkar, Fazlul H. ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Pathol, Karmanos Canc Inst, Detroit, MI 48201 USA

来源：

CANCER TREATMENT REVIEWS | 2010年 / 36卷 / 02期

关键词：

FoxM1; Cancer; Cell signaling pathway; Chemopreventive agents; NF-KAPPA-B; C-MYC PROMOTER; FACTOR FOXM1; NUCLEAR TRANSLOCATION; CELL-PROLIFERATION; DOWNSTREAM TARGET; HEPATOCYTE ENTRY; OXIDATIVE STRESS; GASTRIC-CANCER; FACTOR HFH-11B;

D O I：

10.1016/j.ctrv.2009.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FoxM1 signaling has been reported to be associated with carcinogenesis. Therefore, the FoxM1 may represent a novel therapeutic target, and thus the development of agents that will target FoxM1 is likely to have significant therapeutic impact on human cancer. This review describes the mechanisms of signal transduction associated with FoxM1 and provides emerging evidence in support of its role in the carcinogenesis. Further, we summarize data on several FoxM1 inhibitors especially "chemopreventive agents" and these agents could be useful for targeted inactivation of FoxM1, which indeed could become a novel approach for the prevention and/or treatment of human cancer. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：151 / 156

页数：6

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