Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse

被引：46

作者：

Reichel, Carmela M. ^{[1
]}

See, Ronald E. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

来源：

PSYCHOPHARMACOLOGY | 2010年 / 210卷 / 03期

关键词：

Methamphetamine; Modafinil; Reinstatement; Relapse; Self-administration; Abstinence; COCAINE-SEEKING; DRUG-SEEKING; DOPAMINE TRANSPORTERS; GLUTAMATE RELEASE; DOUBLE-BLIND; IN-VIVO; BEHAVIOR; EXTINCTION; ABSTINENCE; RECEPTORS;

D O I：

10.1007/s00213-010-1828-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modafinil (ProvigilA (R)) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention. We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking. Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone. These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.

引用

页码：337 / 346

页数：10

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