CTLA4 gene variations and haplotypes in patients with lung cancer

被引：34
作者：
Khaghanzadeh, Narges [1 ]
Erfani, Nasrollah [2 ]
Ghayumi, Mohammad Ali [3 ]
Ghaderi, Abbas [1 ,2 ]
机构：
[1] Shiraz Univ Med Sci, Dept Immunol, Shiraz, Iran
[2] Shiraz Univ Med Sci, Inst Canc Res, Shiraz, Iran
[3] Shiraz Univ Med Sci, Dept Internal Med, Shiraz, Iran
来源：
CANCER GENETICS AND CYTOGENETICS | 2010年 / 196卷 / 02期
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; BREAST-CANCER; JAPANESE PATIENTS; PROMOTER REGION; POLYMORPHISM; ASSOCIATION; ANTIGEN-4; SUSCEPTIBILITY; POPULATION; ALLELE;
D O I：
10.1016/j.cancergencyto.2009.09.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The CTLA4 protein downmodulates and terminates immune responses by sending inhibitory signals to activated T cells. In this study, six main single-nucleotide polymorphisms of the CTLA4 gene were investigated in 127 lung cancer patients and 124 healthy control subjects: -1722 T/C, -1661 A/G, -318 CIT. +49A1G, +1822 C/T, and +6230 A/G (CT60). Statistical analyses revealed no significant differences in the frequencies of genotypes, alleles, and haplotypes between patients and control subjects. We also could not find significant association between CTLA4 variants and any defined lung tumor type. These six single-nucleotide polymorphisms in CTLA4 were not associated with susceptibility to lung cancer in Iranian population. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：171 / 174
页数：4
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