Preparation and chromatographic evaluation of a chiral stationary phase based on carboxymethyl-β-cyclodextrin for high-performance liquid chromatography

被引：27
作者：
Zhou, Min [1 ,2 ]
Long, Yuande [1 ]
Zhi, Yonggang [1 ]
Xu, Xiaoying [1 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 640041, Sichuan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 09期
关键词：
Enantioseparation; Carboxymethyl-beta-cyclodextrin; Chiral stationary phase; Chemical bonding; Reversed-phase; RETENTION BEHAVIOR; AMINO-ACIDS; ENANTIOMERIC SEPARATION; CLICK CHEMISTRY; SILICA-GEL; RECOGNITION; HPLC; ENANTIOSEPARATION; ADDITIVES; DRUGS;
D O I：
10.1016/j.cclet.2017.10.039
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
chiral stationary phase (CSP) was prepared by chemically bonding carboxymethyl-beta-cyclodextrin (CM-beta-CD) onto 3-aminopropyl silica gel through amidation reaction in water solution and was characterized by Fourier transform infrared spectroscopy (FT-IR), element analysis (EA) and thermal gravimetry analysis (TGA). The chromatographic performance was evaluated with 24 racemates under reversed phase conditions. The effect of salt, organic modifier, mobile phase pH and structures of analytes were discussed. In comparison with native beta-CD bonded column, CYCLOBOND I 2000, CM-beta-CD CSP exhibited enhanced enantioseparation. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1399 / 1403
页数：5
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