Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells

被引：0
|
作者：
Lee, YH
Bae, SS
Seo, JK
Choi, I
Ryu, SH
Suh, PG [1 ]
机构：
[1] Pohang Univ Sci & Technol, Dept Life Sci, Pohang 790784, South Korea
[2] Pohang Univ Sci & Technol, Sch Environm Engn, Div Mol & Life Sci, Pohang 790784, South Korea
[3] Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
来源：
MOLECULES AND CELLS | 2000年 / 10卷 / 04期
关键词：
interleukin-6; PC12; cells; phospholipase C-gamma 1; signal transduction; tyrosine phosphorylation;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phospholipase C (PLC)-gamma 1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-gamma 1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-gamma 1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine, These results suggest-that PLC-gamma 1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.
引用
收藏
页码：469 / 474
页数：6
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