Bio-orthogonal chemistry enables solid phase synthesis and HPLC and gel-free purification of long RNA oligonucleotides†

被引：10

作者：

He, Muhan ^{[1
]}

Wu, Xunshen ^{[1
]}

Mao, Song ^{[1
]}

Haruehanroengra, Phensinee ^{[1
]}

Khan, Irfan ^{[1
]}

Sheng, Jia ^{[1
]}

Royzen, Maksim ^{[1
]}

机构：

[1] SUNY Albany, Dept Chem, Albany, NY 12222 USA

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 35期

关键词：

STRATEGY;

D O I：

10.1039/d1cc00096a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solid phase synthesis of RNA oligonucleotides which are over 100-nt in length remains challenging due to the complexity of purification of the target strand from failure sequences. This work describes a non-chromatographic strategy that will enable routine solid phase synthesis of long RNA strands.

引用

收藏

页码：4263 / 4266

页数：4

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