Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

被引：85

作者：

Zhang, Yongfa ^{[1
]}

Lu, Xiaoyang ^{[2
,3
]}

Tai, Bai ^{[1
]}

Li, Weijia ^{[1
]}

Li, Tao ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Affiliated Hosp, Kunhua Hosp, Dept Neurosurg,Peoples Hosp Yunnan Prov 5, Kunming, Yunnan, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, Dept Neurosurg, Sch Med, Hangzhou, Peoples R China

[3] Rhein Westfal TH Aachen, Univ Hosp Aachen, Translat Neurosurg & Neurobiol, Aachen, Germany

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2021年 / 15卷

基金：

中国国家自然科学基金;

关键词：

ferroptosis; programmed cell death; iron overload; lipid peroxidation; ischemic stroke; hemorrhagic stroke; glutathione inhibition; CELL-DEATH; LIPID-PEROXIDATION; SYSTEM X(C)(-); BRAIN-INJURY; MOLECULAR-MECHANISMS; HEPCIDIN EXPRESSION; GLUTAMATE RELEASE; OXIDATIVE STRESS; IRON; ISCHEMIA;

D O I：

10.3389/fncel.2021.615372

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function of glutathione-dependent peroxidase 4 (GPX4), and system x(c)(-), all of which finally lead to the over-accumulation of lipid peroxides in the cell. Ferroptosis has been reported to play an important role in the pathophysiological process of various cancers. In recent years, much evidence also proved that ferroptosis is involved in the progress of cerebral stroke. In this review, we summarized the characteristics of ferroptosis and the potential relationship between ferroptosis and ischemic and hemorrhagic stroke, to provide new targets and ideas for the therapy of stroke.

引用

页数：10

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