Regulation of nuclear mTORC1

被引：1

作者：

Zhou, Xin ^{[1
]}

Zhong, Yanghao ^{[1
,2
]}

Zhang, Jin ^{[1
,3
,4
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Biomed Sci Grad Program, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 03期

关键词：

RAPTOR; spatial compartmentalization; protein kinase; nuclear translocation; signaling specificity;

D O I：

10.1080/23723556.2021.1896348

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear compartment.

引用

页数：3

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