Effect of coumarins on HL-60 cell differentiation

被引：0

作者：

Kawaii, S ^{[1
]}

Tomono, Y ^{[1
]}

Katase, E ^{[1
]}

Ogawa, K ^{[1
]}

Yano, M ^{[1
]}

机构：

[1] Natl Inst Fruit Tree Sci, Shizuoka 4240204, Japan

来源：

ANTICANCER RESEARCH | 2000年 / 20卷 / 04期

关键词：

HL-60 cell differentiation; coumarins; esculetin; nordalbergin; 6,7-dihydroxy-4-methylcoumarin; imperatorin;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, nordalbergin, 6,7-dihydroxy-4- methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage. The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.

引用

页码：2505 / 2512

页数：8

共 33 条

[21] NEICHI T, 1983, BIOCHIM BIOPHYS ACTA, V753, P130
[22] OSTERM VK, 1987, P NATL ACAD SCI USA, V84, P2610
[23] PANOSSIAN AG, 1984, BIOMED BIOCHIM ACTA, V43, P1351
[24] REISS M, 1986, CANCER TREAT REP, V70, P201
[25] INHIBITORY EFFECTS OF FUROCOUMARINS IN SALMONELLA-TYPHIMURIUM TA98 ON THE MUTAGENICITY OF DICTAMNINE AND RUTACRIDONE, PROMUTAGENS FROM RUTA-GRAVEOLENS L
SCHIMMER, O
KIEFER, J
PAULINI, H
[J]. MUTAGENESIS, 1991, 6 (06) : 501 - 506
[26] SEKIYA K, 1982, BIOCHIM BIOPHYS ACTA, V713, P68
[27] CITRUS COUMARINS
STANLEY, WL
JURD, L
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1971, 19 (06) : 1106 - +
[28] TANAKA H, 1982, BIOCHEM J, V204, P713, DOI 10.1042/bj2040713
[29] Tanaka T, 1998, CANCER RES, V58, P2550
[30] Assessment of neuronal viability with Alamar blue in cortical and granule cell cultures
White, MJ
DiCaprio, MJ
Greenberg, DA
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1996, 70 (02) : 195 - 200

← 1 2 3 4 →