Effect of coumarins on HL-60 cell differentiation

被引:0
作者
Kawaii, S [1 ]
Tomono, Y [1 ]
Katase, E [1 ]
Ogawa, K [1 ]
Yano, M [1 ]
机构
[1] Natl Inst Fruit Tree Sci, Shizuoka 4240204, Japan
关键词
HL-60 cell differentiation; coumarins; esculetin; nordalbergin; 6,7-dihydroxy-4-methylcoumarin; imperatorin;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, nordalbergin, 6,7-dihydroxy-4- methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage. The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.
引用
收藏
页码:2505 / 2512
页数:8
相关论文
共 33 条
  • [1] THE ROLE OF FATTY-ACID METABOLITES IN THE DIFFERENTIATION OF THE HUMAN MONOCYTE-LIKE CELL-LINE U937
    BOMALASKI, JS
    FREUNDLICH, B
    STEINER, S
    CLARK, MA
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1988, 44 (01) : 51 - 57
  • [2] INDUCTION OF DIFFERENTIATION OF THE HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE (HL-60) BY RETINOIC ACID
    BREITMAN, TR
    SELONICK, SE
    COLLINS, SJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05): : 2936 - 2940
  • [3] Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice
    Cai, YN
    Kleiner, H
    Johnston, D
    Dubowski, A
    Bostic, S
    Ivie, W
    DiGiovanni, J
    [J]. CARCINOGENESIS, 1997, 18 (08) : 1521 - 1527
  • [4] Inhibitory effects of naturally occurring coumarins on the metabolic activation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured mouse keratinocytes
    Cai, YN
    BaerDubowska, W
    AshwoodSmith, M
    DiGiovanni, J
    [J]. CARCINOGENESIS, 1997, 18 (01) : 215 - 222
  • [5] COUMARINS AND ANTIPLATETLET AGGREGATION CONSTITUENTS FROM ZANTHOXYLUM-SCHINIFOLIUM
    CHEN, IS
    LIN, YC
    TSAI, IL
    TENG, CM
    KO, FN
    ISHIKAWA, T
    ISHII, H
    [J]. PHYTOCHEMISTRY, 1995, 39 (05) : 1091 - 1097
  • [6] TERMINAL DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA-CELLS INDUCED BY DIMETHYL-SULFOXIDE AND OTHER POLAR COMPOUNDS
    COLLINS, SJ
    RUSCETTI, FW
    GALLAGHER, RE
    GALLO, RC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (05) : 2458 - 2462
  • [7] DEGOS L, 1990, LEUKEMIA RES, V14, P717, DOI 10.1016/0145-2126(90)90101-E
  • [8] EDENHARDER R, 1995, MUTAT RES-GENET TOX, V345, P57, DOI 10.1016/0165-1218(95)90070-5
  • [9] CHEMOSYSTEMATICS IN RUTACEAE .9. COUMARINS IN RUTACEAE
    GRAY, AI
    WATERMAN, PG
    [J]. PHYTOCHEMISTRY, 1978, 17 (05) : 845 - 864
  • [10] HARRIS PE, 1985, CANCER RES, V45, P3090