Effect of coumarins on HL-60 cell differentiation

被引：0
作者：
Kawaii, S [1 ]
Tomono, Y [1 ]
Katase, E [1 ]
Ogawa, K [1 ]
Yano, M [1 ]
机构：
[1] Natl Inst Fruit Tree Sci, Shizuoka 4240204, Japan
来源：
ANTICANCER RESEARCH | 2000年 / 20卷 / 04期
关键词：
HL-60 cell differentiation; coumarins; esculetin; nordalbergin; 6,7-dihydroxy-4-methylcoumarin; imperatorin;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, nordalbergin, 6,7-dihydroxy-4- methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage. The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.
引用
收藏
页码：2505 / 2512
页数：8
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