Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

被引：11

作者：

Kuo, Ping-Chung ^{[1
]}

Tai, Shih-Huang ^{[2
,3
,4
]}

Hung, Ching-Che ^{[5
]}

Hwang, Tsong-Long ^{[6
,7
,8
]}

Kuo, Liang-Mou ^{[9
,10
]}

Lam, Sio Hong ^{[1
]}

Cheng, Kun-Ching ^{[11
]}

Kuo, Daih-Huang ^{[12
]}

Hung, Hsin-Yi ^{[1
]}

Wu, Tian-Shung ^{[1
,12
]}

机构：

[1] Natl Cheng Kung Univ, Sch Pharm, Coll Med, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ, Med Ctr & Med Sch, Dept Surg, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Med Ctr & Med Sch, Dept Anesthesiol, Tainan 701, Taiwan

[4] Natl Cheng Kung Univ, Med Ctr & Med Sch, Inst Biomed Engn, Tainan 701, Taiwan

[5] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

[6] Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Hlth Aging Res Ctr,Chinese Herbal Med Res Team, Taoyuan 333, Taiwan

[7] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan

[8] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med,Res Ctr Ind Human Ecol, Taoyuan 333, Taiwan

[9] Chang Gung Mem Hosp Chia Yi, Dept Gen Surg, Chiayi 613, Taiwan

[10] Chang Gung Univ, Sch Med, Coll Med, Taoyuan 333, Taiwan

[11] Taiwan Sugar Res Inst, Tainan 70176, Taiwan

[12] Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care, Pingtung 907, Taiwan

来源：

BIOORGANIC CHEMISTRY | 2021年 / 108卷

关键词：

Fomitopsis pinicola; Fomitopsidaceae; Triterpenoid; Antiinflammatory; LANOSTANE TRITERPENOIDS; ACIDS;

D O I：

10.1016/j.bioorg.2020.104562

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 +/- 0.44 and 2.50 +/- 0.64 mu M, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

引用

页数：11

共 26 条

[1] 5-DEHYDROKAROUNIDIOL [D-C-FRIEDO-OLEANA-5,7,9(11)-TRIENE-3-ALPHA,29-DIOL], A NOVEL TRITERPENE FROM TRICHOSANTHES-KIRILOWII MAXIM [J].