Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS-MS and LS-MS)

被引：25

作者：

Bessa, Carliani D. P. B. ^{[1
]}

de Andrade, Jean P. ^{[1
]}

de Oliveira, Renata S. ^{[2
]}

Domingos, Eloilson ^{[3
]}

Santos, Heloa ^{[3
]}

Romao, Wanderson ^{[3
]}

Bastida, Jaume ^{[4
]}

Borges, Warley S. ^{[1
]}

机构：

[1] Univ Fed Espirito Santo, Dept Quim, Vitoria, ES, Brazil

[2] Univ Sao Paulo, Dept Bot, Inst Biociencias, BR-05508900 Sao Paulo, SP, Brazil

[3] Univ Fed Espirito Santo, Dept Quim, Lab Petroleom & Quim Forense, BR-29075910 Vitoria, ES, Brazil

[4] Univ Barcelona, Fac Farm, Grp Prod Nat, Dept Biol Sanitat & Medi Ambient, E-08028 Barcelona, Spain

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2017年 / 28卷 / 05期

关键词：

Amaryllidaceae; Hippeastrum aulicum; CGC-MS; PS-MS/LS-MS; isoquinoline alkaloids; PAPER SPRAY IONIZATION; CRININE-TYPE ALKALOIDS; PLANTS; GC/MS;

D O I：

10.21577/0103-5053.20160234

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others. Mass spectrometry (MS) studies based on capillary gas chromatography (CGC), paper spray (PS), and leaf spray (LS) ionization were carried out for alkaloid investigation of the native Brazilian species Hippeastrum aulicum, along with nuclear magnetic resonance (NMR) techniques. Thirty-one alkaloids were identified including the new compound haemanthamine N-oxide. The results from PS-and LS-MS techniques were consistent with those observed in CGC-MS analysis. To the best of our knowledge, it is the first study combining NMR, CGC-MS and the ambient ionization-mass spectrometry (PS-and LS-MS) on Amaryllidaceae plants.

引用

页码：819 / 830

页数：12