Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation)

被引：16

作者：

Komissarov, Andrey ^{[1
]}

Fadeev, Artem ^{[1
]}

Sergeeva, Maria ^{[2
]}

Petrov, Sergey ^{[2
]}

Sintsova, Kseniya ^{[1
]}

Egorova, Anna ^{[1
]}

Pisareva, Maria ^{[1
]}

Buzitskaya, Zhanna ^{[1
]}

Musaeva, Tamila ^{[3
]}

Danilenko, Daria ^{[4
]}

Konovalova, Nadezhda ^{[4
]}

Petrova, Polina ^{[4
]}

Stolyarov, Kirill ^{[5
]}

Smorodintseva, Elizaveta ^{[6
]}

Burtseva, Elena ^{[7
]}

Krasnoslobodtsev, Kirill ^{[7
]}

Kirillova, Elena ^{[7
]}

Karpova, Lyudmila ^{[8
]}

Eropkin, Mikhail ^{[4
]}

Sominina, Anna ^{[6
]}

Grudinin, Mikhail ^{[1
]}

机构：

[1] Minist Healthcare Russian Federat, Lab Mol Virol & Genet Engn, WHO Recognized Natl Influenza Ctr Russian Federat, Res Inst Influenza, Prof Popova 15-17, St Petersburg 197376, Russia

[2] Minist Healthcare Russian Federat, Res Inst Influenza, Lab Influenza Vaccines, St Petersburg, Russia

[3] Minist Healthcare Russian Federat, Res Inst Influenza, Lab Mol Virol & Genet Engn, St Petersburg, Russia

[4] Minist Healthcare Russian Federat, Res Inst Influenza, Lab Evolutionary Variabil Influenza Viruses, WHO Recognized Natl Influenza Ctr Russian Federat, St Petersburg, Russia

[5] Minist Healthcare Russian Federat, Res Inst Influenza, Dept IT, WHO Recognized Natl Influenza Ctr Russian Federat, St Petersburg, Russia

[6] Minist Healthcare Russian Federat, Res Inst Influenza, Biotechnol Lab, WHO Recognized Natl Influenza Ctr Russian Federat, St Petersburg, Russia

[7] WHO Recognized Natl Influenza Ctr Russian Federat, Fed Res Ctr Epidemiol & Microbiol, Moscow, Russia

[8] WHO Recognized Natl Influenza Ctr Russian Federat, Lab Influenza & ARI Epidemiol, Res Inst Influenza, St Petersburg, Russia

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2016年 / 10卷 / 04期

关键词：

A(H1N1)pdm09; high-throughput nucleotide sequencing; influenza; Russia; A VIRUS; NS1; PROTEIN; SHUTOFF;

D O I：

10.1111/irv.12389

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole-genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP, E125D in NS1, M105T in NP, Q208K in M1, and N204S in PA-X) that probably emerged before the beginning of 2015/2016 epidemic season.

引用

页码：247 / 253

页数：7

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