Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives

被引：42

作者：

Cuellar, MA

Salas, C

Cortés, MJ

Morello, A

Maya, JD

Preite, MD

机构：

[1] Pontificia Univ Catolica Chile, Fac Quim, Dept Quim Organ, Santiago, Chile

[2] Univ Chile, ICBM, Fac Med, Programa Farmacol Mol & Clin, Santiago 7, Chile

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 12期

关键词：

D O I：

10.1016/S0968-0896(03)00193-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Diels-Alder reaction between two polygodial-derived dienes and simple quinones to yield substituted naphtho- and anthraquinones, is described. The in vitro trypanocide activity for the series was determined. Two of the new compounds showed an activity ten and two times higher, respectively, than nifurtimox and benznidazole, the medicines of choice for the treatment of the acute Chagas' disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2489 / 2497

页数：9

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