Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides

被引：101

作者：

Yan, Hui ^{[1
]}

Xie, Yupeng ^{[1
]}

Sun, Shiguang ^{[1
]}

Sun, Xiaodi ^{[1
]}

Ren, Fengxia ^{[2
]}

Shi, Qirong ^{[1
]}

Wang, Suhui ^{[1
]}

Zhang, Weidong ^{[1
]}

Li, Xiumin ^{[1
]}

Zhang, Jing ^{[1
]}

机构：

[1] Gen Hosp Beijing Mil Reg, Dept Pharm, Beijing 100700, Peoples R China

[2] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2010年 / 82卷 / 03期

关键词：

Astragalus mongholicus polysaccharides; Mice; MDA; FT-IR; GC; METHYLATION;

D O I：

10.1016/j.carbpol.2010.05.026

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polysaccharide from Astragalus membranaceus was investigated for its antioxidant potential. Major functional groups of the polysaccharide were analyzed by Fourier transmission-infrared spectroscopy (FT-IR) and gas chromatography (GC). Analysis of the polysaccharide from A. membranaceus revealed four sugars: glucose, galactose, mannose, arabinose. Mannose was the major components, followed by glucose, mannose and arabinose. The presence of aromatic C=C bands in the infrared (1600 cm(-1)) suggested the presence of polyphenols. The intense bands in the infrared O-H and C=O regions were attributed mainly to the presence of furan ring. Pharmaceutical experiments showed that administration of Astragalus mongholicus polysaccharides could significantly increase serum and liver antioxidant enzyme activities in mice and decrease peroxidative lipid levels. In conclusion, A. mongholicus polysaccharides may offer good protection against oxidative stress. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：636 / 640

页数：5

共 21 条

[1]

BEUTLER E, 1963, J LAB CLIN MED, V61, P882

[2] Sweet cassava polysaccharide extracts protects against CCl4 liver injury in Wistar rats [J].

Charles, Albert Linton ;

Huang, Tzou-Chi .

FOOD HYDROCOLLOIDS, 2009, 23 (06) :1494-1500

[3]

Claiborne A., 1986, CRC Handbook of Methods for Oxygen Radical Research, P283

[4]

Echeonwu GON, 2008, AFR J MICROBIOL RES, V2, P120

[5] Purification and characterization of an extracellular polysaccharide from haloalkalophilic Bacillus sp I-450 [J].

Ganesh Kumar, C ;

Joo, HS ;

Choi, JW ;

Koo, YM ;

Chang, CS .

ENZYME AND MICROBIAL TECHNOLOGY, 2004, 34 (07) :673-681

[6]

GUNZLER WA, 1986, HDB METHODS OXYGEN R, P285

[7] Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia [J].

Huang, Guan-Cheng ;

Wu, Lien-Sheng ;

Chen, Lih-Geeng ;

Yang, Ling-Ling ;

Wang, Ching-Chiung .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 109 (02) :229-235

[8]

KAKKAR P, 1984, INDIAN J BIOCHEM BIO, V21, P130

[9] Chemical analysis of Radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations [J].

Ma, XQ ;

Shi, Q ;

Duan, JA ;

Dong, TTX ;

Tsim, KWK .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (17) :4861-4866

[10] LIPID-PEROXIDATION IN TUMOR-CELLS [J].

MASOTTI, L ;

CASALI, E ;

GALEOTTI, T .

FREE RADICAL BIOLOGY AND MEDICINE, 1988, 4 (06) :377-386

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