MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5)

被引：19

作者：

Li, Dong ^{[1
]}

Liu, Yu ^{[1
]}

Li, Hua ^{[1
]}

Peng, Jing-Jing ^{[1
]}

Tan, Yan ^{[2
]}

Zou, Qiang ^{[3
]}

Song, Xiao-Feng ^{[4
]}

Du, Min ^{[1
]}

Yang, Zheng-Hui ^{[5
]}

Tan, Yong ^{[1
]}

Zhou, Jin-Jun ^{[1
]}

Xu, Tao ^{[1
]}

Fu, Zeng-Qiang ^{[1
]}

Feng, Jian-Qiong ^{[1
]}

Cheng, Peng ^{[1
]}

Chen, Tao ^{[1
]}

Wei, Dong ^{[1
]}

Su, Xiao-Mei ^{[1
]}

Liu, Huan-Yi ^{[1
]}

Qi, Zhong-Chun ^{[1
]}

Tang, Li-Jun ^{[6
]}

Wang, Tao ^{[6
]}

Guo, Xin ^{[7
]}

Hu, Yong-He ^{[1
]}

Zhang, Tao ^{[1
]}

机构：

[1] Chengdu Mil Gen Hosp, Dept Oncol, Chengdu 610083, Sichuan, Peoples R China

[2] Chengdu Mil Gen Hosp, Dept Sci Res & Training, Chengdu 610083, Sichuan, Peoples R China

[3] Chengdu Med Coll, Inst Aging & Immun, Chengdu 610083, Sichuan, Peoples R China

[4] Chengdu Mil Gen Hosp, Dept Hlth Care, Chengdu 610083, Sichuan, Peoples R China

[5] Chengdu Mil Gen Hosp, Dept Neurol, Chengdu 610083, Sichuan, Peoples R China

[6] Chengdu Mil Gen Hosp, Dept Gen Surg, Chengdu 610083, Sichuan, Peoples R China

[7] Chengdu Mil Gen Hosp, Dept Lab Med, Chengdu 610083, Sichuan, Peoples R China

来源：

FEBS LETTERS | 2015年 / 589卷 / 01期

基金：

中国国家自然科学基金;

关键词：

microRNA-1; Apoptosis inhibitor 5; Apoptosis; Hepatocellular carcinoma; Hepatoma cell; CANCER CELLS; AAC-11; MIR-1; EXPRESSION; GENE; PROGNOSIS; INVASION; MIRNA-1;

D O I：

10.1016/j.febslet.2014.11.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although microRNA-1 (miR-1) is a known liver cancer suppressor, the role of miR-1 in apoptosis of hepatoma cells has remained largely unknown. Our study shows that ectopic miR-1 overexpression induced apoptosis of liver hepatocellular carcinoma (HepG2) cells. Apoptosis inhibitor 5 (API-5) was found to be a potential regulator of miR-1 induced apoptosis, using a bioinformatics approach. Furthermore, an inverse relationship between miR-1 and API-5 expression was observed in human liver cancer tissues and adjacent normal liver tissues. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. Our study provides a novel regulatory mechanism of miR-1 in the apoptosis of hepatoma cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：68 / 76

页数：9

共 50 条

[31] miRNA-125a-5p inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting TP53 regulated inhibitor of apoptosis 1 and Bcl-2-like-2 protein
Ming, Ma
Ying, Ma
Ling, Ma
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 18 (02) : 1196 - 1202
[32] MicroRNA-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11
Shang, Guowei
Mi, Yang
Mei, Yingwu
Wang, Guanghui
Wang, Yadong
Li, Xinjie
Wang, Yisheng
Li, Yuebai
Zhao, Guoqiang
ONCOLOGY LETTERS, 2018, 15 (05) : 7265 - 7272
[33] microRNA-10b promotes the apoptosis of bovine ovarian granulosa cells by targeting plasminogen activator inhibitor-1
Guo, Lewei
Huang, Qixuan
Zhao, Jing
Liu, Hongyu
Lu, Wenfa
Wang, Jun
THERIOGENOLOGY, 2021, 176 : 206 - 216
[34] MicroRNA-409-5p inhibits cell proliferation, and induces G2/M phase arrest and apoptosis by targeting DLGAP5 in ovarian cancer cells
Li, Weiwei
Lin, Ji
Huang, Jianfen
Chen, Zhuoying
Sheng, Qunying
Yang, Fang
Yang, Xue
Cui, Xiaojie
ONCOLOGY LETTERS, 2022, 24 (02)
[35] MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1
Ji, Fang
Zhang, Hao
Wang, Yang
Li, Ming
Xu, Weidong
Kang, Yifan
Wang, Zhiwei
Wang, Zimin
Cheng, Ping
Tong, Dake
Li, Cheng
Tang, Hao
BONE, 2013, 56 (01) : 220 - 226
[36] MicroRNA-18 promotes apoptosis of islet β-cells via targeting NAV1
Fei, Honghua
Shi, Mingyan
Chen, Lianhong
Wang, Zhe
Suo, Lihua
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 18 (01) : 389 - 396
[37] MiRNA-1469 promotes lung cancer cells apoptosis through targeting STAT5a
Xu, Chengshan
Zhang, Ling
Li, Hengheng
Liu, Zhihua
Duan, Lianning
Lu, Chengrong
AMERICAN JOURNAL OF CANCER RESEARCH, 2015, 5 (03): : 1180 - +
[38] MicroRNA-383-5p restrains the proliferation and migration of breast cancer cells and promotes apoptosis via inhibition of PD-L1
Azarbarzin, Shirin
Hosseinpour-Feizi, Mohammad Ali
Khojasteh, Seyed Mahdi Banan
Baradaran, Behzad
Safaralizadeh, Reza
LIFE SCIENCES, 2021, 267
[39] lncRNA LINC00960 promotes apoptosis by sponging ubiquitin ligase Nrdp1-targeting miR-183-5p
Yang, Hao
Jiang, Tianxia
Fan, Libin
Qiu, Xiaobo
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023, 55 (01): : 91 - 102
[40] MicroRNA-1269a Promotes Proliferation and Arrest of Apoptosis of Glioma Cells by Directly Targeting ATRX
Zhang, Yulian
Wang, Qi
Luo, Na
Liu, Jiang
Ren, Hongxiang
Shao, Xu
Zhang, Li
Yu, Yanbing
FRONTIERS IN ONCOLOGY, 2020, 10

← 1 2 3 4 5 →