MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5)

被引：19

作者：

Li, Dong ^{[1
]}

Liu, Yu ^{[1
]}

Li, Hua ^{[1
]}

Peng, Jing-Jing ^{[1
]}

Tan, Yan ^{[2
]}

Zou, Qiang ^{[3
]}

Song, Xiao-Feng ^{[4
]}

Du, Min ^{[1
]}

Yang, Zheng-Hui ^{[5
]}

Tan, Yong ^{[1
]}

Zhou, Jin-Jun ^{[1
]}

Xu, Tao ^{[1
]}

Fu, Zeng-Qiang ^{[1
]}

Feng, Jian-Qiong ^{[1
]}

Cheng, Peng ^{[1
]}

Chen, Tao ^{[1
]}

Wei, Dong ^{[1
]}

Su, Xiao-Mei ^{[1
]}

Liu, Huan-Yi ^{[1
]}

Qi, Zhong-Chun ^{[1
]}

Tang, Li-Jun ^{[6
]}

Wang, Tao ^{[6
]}

Guo, Xin ^{[7
]}

Hu, Yong-He ^{[1
]}

Zhang, Tao ^{[1
]}

机构：

[1] Chengdu Mil Gen Hosp, Dept Oncol, Chengdu 610083, Sichuan, Peoples R China

[2] Chengdu Mil Gen Hosp, Dept Sci Res & Training, Chengdu 610083, Sichuan, Peoples R China

[3] Chengdu Med Coll, Inst Aging & Immun, Chengdu 610083, Sichuan, Peoples R China

[4] Chengdu Mil Gen Hosp, Dept Hlth Care, Chengdu 610083, Sichuan, Peoples R China

[5] Chengdu Mil Gen Hosp, Dept Neurol, Chengdu 610083, Sichuan, Peoples R China

[6] Chengdu Mil Gen Hosp, Dept Gen Surg, Chengdu 610083, Sichuan, Peoples R China

[7] Chengdu Mil Gen Hosp, Dept Lab Med, Chengdu 610083, Sichuan, Peoples R China

来源：

FEBS LETTERS | 2015年 / 589卷 / 01期

基金：

中国国家自然科学基金;

关键词：

microRNA-1; Apoptosis inhibitor 5; Apoptosis; Hepatocellular carcinoma; Hepatoma cell; CANCER CELLS; AAC-11; MIR-1; EXPRESSION; GENE; PROGNOSIS; INVASION; MIRNA-1;

D O I：

10.1016/j.febslet.2014.11.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although microRNA-1 (miR-1) is a known liver cancer suppressor, the role of miR-1 in apoptosis of hepatoma cells has remained largely unknown. Our study shows that ectopic miR-1 overexpression induced apoptosis of liver hepatocellular carcinoma (HepG2) cells. Apoptosis inhibitor 5 (API-5) was found to be a potential regulator of miR-1 induced apoptosis, using a bioinformatics approach. Furthermore, an inverse relationship between miR-1 and API-5 expression was observed in human liver cancer tissues and adjacent normal liver tissues. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. Our study provides a novel regulatory mechanism of miR-1 in the apoptosis of hepatoma cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：68 / 76

页数：9

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