MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5)

被引：19

作者：

Li, Dong ^{[1
]}

Liu, Yu ^{[1
]}

Li, Hua ^{[1
]}

Peng, Jing-Jing ^{[1
]}

Tan, Yan ^{[2
]}

Zou, Qiang ^{[3
]}

Song, Xiao-Feng ^{[4
]}

Du, Min ^{[1
]}

Yang, Zheng-Hui ^{[5
]}

Tan, Yong ^{[1
]}

Zhou, Jin-Jun ^{[1
]}

Xu, Tao ^{[1
]}

Fu, Zeng-Qiang ^{[1
]}

Feng, Jian-Qiong ^{[1
]}

Cheng, Peng ^{[1
]}

Chen, Tao ^{[1
]}

Wei, Dong ^{[1
]}

Su, Xiao-Mei ^{[1
]}

Liu, Huan-Yi ^{[1
]}

Qi, Zhong-Chun ^{[1
]}

Tang, Li-Jun ^{[6
]}

Wang, Tao ^{[6
]}

Guo, Xin ^{[7
]}

Hu, Yong-He ^{[1
]}

Zhang, Tao ^{[1
]}

机构：

[1] Chengdu Mil Gen Hosp, Dept Oncol, Chengdu 610083, Sichuan, Peoples R China

[2] Chengdu Mil Gen Hosp, Dept Sci Res & Training, Chengdu 610083, Sichuan, Peoples R China

[3] Chengdu Med Coll, Inst Aging & Immun, Chengdu 610083, Sichuan, Peoples R China

[4] Chengdu Mil Gen Hosp, Dept Hlth Care, Chengdu 610083, Sichuan, Peoples R China

[5] Chengdu Mil Gen Hosp, Dept Neurol, Chengdu 610083, Sichuan, Peoples R China

[6] Chengdu Mil Gen Hosp, Dept Gen Surg, Chengdu 610083, Sichuan, Peoples R China

[7] Chengdu Mil Gen Hosp, Dept Lab Med, Chengdu 610083, Sichuan, Peoples R China

来源：

FEBS LETTERS | 2015年 / 589卷 / 01期

基金：

中国国家自然科学基金;

关键词：

microRNA-1; Apoptosis inhibitor 5; Apoptosis; Hepatocellular carcinoma; Hepatoma cell; CANCER CELLS; AAC-11; MIR-1; EXPRESSION; GENE; PROGNOSIS; INVASION; MIRNA-1;

D O I：

10.1016/j.febslet.2014.11.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although microRNA-1 (miR-1) is a known liver cancer suppressor, the role of miR-1 in apoptosis of hepatoma cells has remained largely unknown. Our study shows that ectopic miR-1 overexpression induced apoptosis of liver hepatocellular carcinoma (HepG2) cells. Apoptosis inhibitor 5 (API-5) was found to be a potential regulator of miR-1 induced apoptosis, using a bioinformatics approach. Furthermore, an inverse relationship between miR-1 and API-5 expression was observed in human liver cancer tissues and adjacent normal liver tissues. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. Our study provides a novel regulatory mechanism of miR-1 in the apoptosis of hepatoma cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：68 / 76

页数：9

共 28 条

[1] Molecular Mechanisms of Hepatocellular Carcinoma [J].

Aravalli, Rajagopal N. ;

Steer, Clifford J. ;

Cressman, Erik N. K. .

HEPATOLOGY, 2008, 48 (06) :2047-2063

[2] RETRACTED: Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis (Retracted Article) [J].

Datta, Jharna ;

Kutay, Huban ;

Nasser, Mohd W. ;

Nuovo, Gerard J. ;

Wang, Bo ;

Majumder, Sarmila ;

Liu, Chang-Gong ;

Volinia, Stefano ;

Croce, Carlo M. ;

Schmittgen, Thomas D. ;

Ghoshal, Kalpana ;

Jacob, Samson T. .

CANCER RESEARCH, 2008, 68 (13) :5049-5058

[3] Hepatocellular carcinoma pathogenesis: from genes to environment [J].

Farazi, Paraskevi A. ;

DePinho, Ronald A. .

NATURE REVIEWS CANCER, 2006, 6 (09) :674-687

[4] MicroRNAs: New Tools for Diagnosis, Prognosis, and Therapy in Hepatocellular Carcinoma? [J].

Giordano, Silvia ;

Columbano, Amedeo .

HEPATOLOGY, 2013, 57 (02) :840-847

[5] The role of microRNAs in liver cancer progression [J].

Huang, S. ;

He, X. .

BRITISH JOURNAL OF CANCER, 2011, 104 (02) :235-240

[6] AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis [J].

Kim, JW ;

Cho, HS ;

Kim, JH ;

Hur, SY ;

Kim, TE ;

Lee, JM ;

Kim, IK ;

Namkoong, SE .

LABORATORY INVESTIGATION, 2000, 80 (04) :587-594

[7] Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo [J].

Koci, Lenka ;

Chlebova, Katarina ;

Hyzdalova, Martina ;

Hofmanova, Jirina ;

Jira, Miroslav ;

Kysela, Petr ;

Kozubik, Alois ;

Kala, Zdenek ;

Krejci, Pavel .

ONCOLOGY LETTERS, 2012, 3 (04) :913-916

[8] MiR-1 Is a Tumor Suppressor in Thyroid Carcinogenesis Targeting CCND2, CXCR4, and SDF-1α [J].

Leone, Vincenza ;

D'Angelo, Daniela ;

Rubio, Ileana ;

de Freitas, Paula Mussnich ;

Federico, Antonella ;

Colamaio, Marianna ;

Pallante, Pierlorenzo ;

Medeiros-Neto, Geraldo ;

Fusco, Alfredo .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (09) :E1388-E1398

[9] MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1 [J].

Li, Dong ;

Yang, Pengyuan ;

Li, Hua ;

Cheng, Peng ;

Zhang, Ling ;

Wei, Dong ;

Su, Xiaomei ;

Peng, Jingjing ;

Gao, Hui ;

Tan, Yong ;

Zhao, Zhenguo ;

Li, Yan ;

Qi, Zhongchun ;

Rui, Yaocheng ;

Zhang, Tao .

LIFE SCIENCES, 2012, 91 (11-12) :440-447

[10] The inhibitory effect of miRNA-1 on ET-1 gene expression [J].

Li, Dong ;

He, Bin ;

Zhang, Huan ;

Shan, Shi-Fu ;

Liang, Qing ;

Yuan, Wen-Jun ;

Ren, An-Jing .

FEBS LETTERS, 2012, 586 (07) :1014-1021

← 1 2 3 →