Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

被引：149
作者：
Alangaden, GJ
Kreiswirth, BN
Aouad, A
Khetarpal, M
Igno, FR
Moghazeh, SL
Manavathu, EK
Lerner, SA
机构：
[1] Wayne State Univ, Sch Med, Div Infect Dis, Detroit, MI 48201 USA
[2] Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI 48201 USA
[3] Publ Hlth Res Inst City New York Inc, TB Ctr, New York, NY 10016 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期
关键词：
D O I：
10.1128/AAC.42.5.1295
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
An A1400G mutation of the ns gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 mu g/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.
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页码：1295 / 1297
页数：3
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