Growth hormone stimulation tests in chronic renal failure with metabolic acidosis

被引:0
作者
Bircan, Z [1 ]
Kervancioglu, M [1 ]
Soran, M [1 ]
Yildirim, I [1 ]
机构
[1] Dicle Univ, Sch Med, Dept Pediat, TR-21280 Diyarbakir, Turkey
来源
ACTA PAEDIATRICA JAPONICA | 1998年 / 40卷 / 01期
关键词
chronic renal failure; growth hormone; metabolic acidosis;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Metabolic acidosis is one of the possible causes of growth retardation in chronic renal failure (CRF). Data about the effect of metabolic acidosis on growth hormone (GPI) secretion in CRF are limited. A study was carried out on eight CRF patients, hospitalized because of severe metabolic acidosis, and eight age-matched prepubertal healthy short children. Growth hormone stimulation tests were done with L-dopa and clonidine before or during acidosis therapy and after the correction of metabolic acidosis. The levels of GH were measured by radio-immunoassay. The mean of the peaks of both tests were used for each patient and statistical significance was tested by Mann-Whitney U and Wilcoxon tests. No difference was found between the GH peaks of the two groups during acidosis and after the correction of acidosis (Wilcoxon test, P > 0.05). In view of this data it was concluded that metabolic acidosis has little effect on GH stimulation tests.
引用
收藏
页码:70 / 72
页数:3
相关论文
共 50 条
[41]   Reversible diabetes mellitus during growth hormone therapy in chronic renal failure [J].
Filler, G ;
Franke, D ;
Amendt, P ;
Ehrich, JHH .
PEDIATRIC NEPHROLOGY, 1998, 12 (05) :405-407
[42]   Growth hormone treatment enhances bone mineralisation in children with chronic renal failure [J].
Van Dyck, M ;
Gyssels, A ;
Proesmans, W ;
Nijs, J ;
Eeckels, R .
EUROPEAN JOURNAL OF PEDIATRICS, 2001, 160 (06) :359-363
[43]   Effects of recombinant human growth hormone in catabolic adults with chronic renal failure [J].
Mehls, O ;
Haas, S .
GROWTH HORMONE & IGF RESEARCH, 2000, 10 :31-37
[44]   Reversible diabetes mellitus during growth hormone therapy in chronic renal failure [J].
Guido Filler ;
Doris Franke ;
Peter Amendt ;
Jochen H. H. Ehrich .
Pediatric Nephrology, 1998, 12 :405-407
[45]   Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy [J].
Darabi, Azadeh ;
Abadi, Javad Mohamadi Taze ;
Sharbaf, Fatemeh Ghane ;
Ghaemi, Nosrat ;
Azarfar, Anoush ;
Ravanshad, Yalda ;
Sarvari, Gholamreza ;
Noghabi, Mina Ekrami ;
Ghahremani, Sara .
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD, 2019, 7 (08) :9883-9892
[46]   Effect of Growth Hormone (GH) therapy on parathyroid hormone metabolism in a girl with GH deficient short stature and chronic renal failure [J].
Fujisawa, Y ;
Kida, K .
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 1996, 9 (05) :555-558
[47]   Growth hormone/insulin-like growth factor system in children with chronic renal failure [J].
Tönshoff, B ;
Kiepe, D ;
Ciarmatori, S .
PEDIATRIC NEPHROLOGY, 2005, 20 (03) :279-289
[48]   Growth hormone/insulin-like growth factor system in children with chronic renal failure [J].
Burkhard Tönshoff ;
Daniela Kiepe ;
Sonia Ciarmatori .
Pediatric Nephrology, 2005, 20 :279-289
[49]   Muscle protein turnover in chronic renal failure patients with metabolic acidosis or normal acid-base balance [J].
Garibotto, G ;
Russo, R ;
Sofia, A ;
Sala, MR ;
Sabatino, C ;
Moscatelli, P ;
Deferrari, G ;
Tizianello, A .
MINERAL AND ELECTROLYTE METABOLISM, 1996, 22 (1-3) :58-61
[50]   Parathyroid hormone, chronic renal failure and the liver [J].
Massry, SG ;
Smogorzewski, M .
KIDNEY INTERNATIONAL, 1997, 52 :S5-S7