Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme

被引：49

作者：

Ohashi, Riuko ^{[1
,2
,3
,4
]}

Martignoni, Guido ^{[5
,6
]}

Hartmann, Arndt ^{[7
]}

Calio, Anna ^{[5
]}

Segala, Diego ^{[6
]}

Stoehr, Christine ^{[7
]}

Wach, Sven ^{[8
]}

Erlmeier, Franziska ^{[7
,9
]}

Weichert, Wilko ^{[9
]}

Autenrieth, Michael ^{[10
]}

Schraml, Peter ^{[2
,3
]}

Rupp, Niels J. ^{[2
,3
]}

Ohe, Chisato ^{[11
]}

Otsuki, Yoshiro ^{[12
]}

Kawasaki, Takashi ^{[13
]}

Kobayashi, Hiroshi ^{[14
]}

Kobayashi, Kazuhiro ^{[15
]}

Miyazaki, Tatsuhiko ^{[15
]}

Shibuya, Hiroyuki ^{[16
]}

Usuda, Hiroyuki ^{[17
]}

Umezu, Hajime ^{[18
]}

Fujishima, Fumiyoshi ^{[19
]}

Furusato, Bungo ^{[20
,21
]}

Osakabe, Mitsumasa ^{[22
]}

Sugai, Tamotsu ^{[22
]}

Kuroda, Naoto ^{[23
]}

Tsuzuki, Toyonori ^{[24
]}

Nagashima, Yoji ^{[25
]}

Ajioka, Yoichi ^{[1
,4
]}

Moch, Holger ^{[2
,3
]}

机构：

[1] Niigata Univ, Histopathol Core Facil, Fac Med, Chuo Ku, 1-757 Asahimachi Dori, Niigata 9518510, Japan

[2] Univ Zurich, Dept Pathol & Mol Pathol, Schmelzbergstr 12, CH-8091 Zurich, Switzerland

[3] Univ Hosp Zurich, Schmelzbergstr 12, CH-8091 Zurich, Switzerland

[4] Niigata Univ, Div Mol & Diagnost Pathol, Grad Sch Med & Dent Sci, Chuo Ku, 1-757 Asahimachi Dori, Niigata 9518510, Japan

[5] Univ Verona, Dept Diagnost & Publ Hlth, Piazzale Ludovico Antonio Scuro 10, I-37134 Verona, Italy

[6] Pederzoli Hosp, Dept Pathol, Via Monte Baldo 24, I-37019 Peschiera Del Garda, Italy

[7] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Pathol, Krankenhausstr 8-10, D-91054 Erlangen, Germany

[8] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Urol & Pediat Urol, Krankenhausstr 12, D-91054 Erlangen, Germany

[9] Tech Univ Munich, Inst Pathol, Trogerstr 18, D-81675 Munich, Germany

[10] Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany

[11] Kansai Med Univ, Dept Pathol & Lab Med, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan

[12] Seirei Hamamatsu Gen Hosp, Dept Pathol, Naka Ku, 2-12-12 Sumiyoshi, Hamamatsu, Shizuoka 4308558, Japan

[13] Niigata Canc Ctr Hosp, Dept Pathol, Chuo Ku, 2-15-3 Kawagishi Cho, Niigata 9518566, Japan

[14] Tachikawa Gen Hosp, Dept Pathol, 1-24 Asahioka, Nagaoka, Niigata 9408621, Japan

[15] Gifu Univ Hosp, Dept Pathol, 1-1 Yanagido, Gifu 5011194, Japan

[16] Niigata City Gen Hosp, Dept Pathol, Chuo Ku, 463-7 Shumoku, Niigata 9501197, Japan

[17] Nagaoka Red Cross Hosp, Dept Diagnost Pathol, 2-297-1 Sensyu, Nagaoka, Niigata 9402085, Japan

[18] Niigata Univ Med & Dent Hosp, Div Pathol, Chuo Ku, 1-754 Asahimachi Dori, Niigata 9518520, Japan

[19] Tohoku Univ, Dept Anat Pathol, Grad Sch Med, Aoba Ku, 2-1 Seityo Machi, Sendai, Miyagi 9808575, Japan

[20] Nagasaki Univ Hosp, Clin Genom Ctr, Canc Genom Unit, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

[21] Nagasaki Univ, Dept Pathol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

[22] Iwate Med Univ, Sch Med, Dept Mol Diagnost Pathol, 2-1-1 Idai Dori, Yahaba, Iwate 0283695, Japan

[23] Kochi Red Cross Hosp, Dept Diagnost Pathol, 1-4-63-11 Hadaminamimachi, Kochi, Kochi 7808562, Japan

[24] Aichi Med Univ Hosp, Dept Surg Pathol, 1-1 Yamkokarimata, Nagakute, Aichi 4801195, Japan

[25] Tokyo Womens Med Univ Hosp, Dept Surg Pathol, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan

来源：

VIRCHOWS ARCHIV | 2020年 / 476卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Chromophobe renal cell carcinoma; Kidney; Mitosis; Necrosis; Prognosis; Sarcomatoid differentiation; The Cancer Genome Atlas (TCGA); Tumor grade; NEUROENDOCRINE; VALIDATION; PARAMETERS; FEATURES; OUTCOMES; SOCIETY; UTILITY; IMPACT; TUMOR;

D O I：

10.1007/s00428-019-02710-w

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A histological grading system of chromophobe renal cell carcinoma (chRCC) is highly desirable to identify approximately 5-10% of tumors at risk for progression. Validation studies failed to demonstrate a correlation between the four-tiered WHO/ISUP grade and outcome. Previous proposals with three-tiered chromophobe grading systems could not be validated. In this study, the presence of sarcomatoid differentiation, necrosis, and mitosis was analyzed in a Swiss cohort (n = 42), an Italian cohort (n = 103), a German cohort (n = 54), a Japanese cohort (n = 119), and The Cancer Genome Atlas cohort (n = 64). All 3 histological parameters were significantly associated with shorter time to tumor progression and overall survival in univariate analysis. Interobserver variability for identification of these parameters was measured by Krippendorff's alpha coefficient and showed high concordance for the identification of sarcomatoid differentiation and tumor necrosis, but only low to medium concordance for the identification of mitosis. Therefore, we tested a two-tiered tumor grading system (low versus high grade) based only on the presence of sarcomatoid differentiation and/or necrosis finding in the combined cohorts (n = 382). pT stage, patient's age (> 65 vs <= 65), lymph node and/or distant metastasis, and the two-tiered grading system (low versus high grade) were significantly associated with overall survival and were independent prognostic parameters in multivariate analysis (Cox proportional hazard). This multi-institutional evaluation of prognostic parameters suggests tumor necrosis and sarcomatoid differentiation as reproducible components of a two-tiered chromophobe tumor grading system.

引用

页码：409 / 418

页数：10

共 39 条

[1] Sarcomatoid renal cell carcinoma: The chromophobe connection [J].

Akhtar, M ;

Tulbah, A ;

Kardar, AH ;

Ali, MA .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1997, 21 (10) :1188-1195

[2] Chromophobe Renal Cell Carcinoma: Histomorphologic Characteristics and Evaluation of Conventional Pathologic Prognostic Parameters in 145 Cases [J].

Amin, Mahul B. ;

Paner, Gladell P. ;

Alvarado-Cabrero, Isabel ;

Young, Andrew N. ;

Stricker, Hans J. ;

Lyles, Robert H. ;

Moch, Holger .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2008, 32 (12) :1822-1834

[3] Prognostic impact of histologic Subtyping of adult renal epithelial neoplasms - An experience of 405 cases [J].

Amin, MB ;

Tamboli, P ;

Javidan, J ;

Stricker, H ;

Venturina, MD ;

Deshpande, A ;

Menon, M .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (03) :281-291

[4]

Brierley JD., 2016, TNM CLASSIFICATION M

[5]

Casuscelli J, 2019, CLIN GENITOURIN CANC

[6] Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma [J].

Casuscelli, Jozefina ;

Weinhold, Nils ;

Gundem, Gunes ;

Wang, Lu ;

Zabor, Emily C. ;

Drill, Esther ;

Wang, Patricia I. ;

Nanjangud, Gouri J. ;

Redzematovic, Almedina ;

Nargund, Amrita M. ;

Manley, Brandon J. ;

Arcila, Maria E. ;

Donin, Nicholas M. ;

Cheville, John C. ;

Thompson, R. Houston ;

Pantuck, Allan J. ;

Russo, Paul ;

Cheng, Emily H. ;

Lee, William ;

Tickoo, Satish K. ;

Ostrovnaya, Irina ;

Creighton, Chad J. ;

Papaemmanuil, Elli ;

Seshan, Venkatraman E. ;

Hakimi, A. Ari ;

Hsieh, James J. .

JCI INSIGHT, 2017, 2 (12)

[7] Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma [J].

Cheville, JC ;

Lohse, CM ;

Zincke, H ;

Weaver, AL ;

Blute, ML .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (05) :612-624

[8] Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading [J].

Dagher, Julien ;

Delahunt, Brett ;

Rioux-Leclercq, Nathalie ;

Egevad, Lars ;

Srigley, John R. ;

Coughlin, Geoffrey ;

Dunglinson, Nigel ;

Gianduzzo, Troy ;

Kua, Boon ;

Malone, Greg ;

Martin, Ben ;

Preston, John ;

Pokorny, Morgan ;

Wood, Simon ;

Yaxley, John ;

Samaratunga, Hemamali .

HISTOPATHOLOGY, 2017, 71 (06) :918-925

[9] The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma [J].

Davis, Caleb F. ;

Ricketts, Christopher J. ;

Wang, Min ;

Yang, Lixing ;

Cherniack, Andrew D. ;

Shen, Hui ;

Buhay, Christian ;

Kang, Hyojin ;

Kim, Sang Cheol ;

Fahey, Catherine C. ;

Hacker, Kathryn E. ;

Bhanot, Gyan ;

Gordenin, Dmitry A. ;

Chu, Andy ;

Gunaratne, Preethi H. ;

Biehl, Michael ;

Seth, Sahil ;

Kaipparettu, Benny A. ;

Bristow, Christopher A. ;

Donehower, Lawrence A. ;

Wallen, Eric M. ;

Smith, Angela B. ;

Tickoo, Satish K. ;

Tamboli, Pheroze ;

Reuter, Victor ;

Schmidt, Laura S. ;

Hsieh, James J. ;

Choueiri, Toni K. ;

Hakimi, A. Ari ;

Chin, Lynda ;

Meyerson, Matthew ;

Kucherlapati, Raju ;

Park, Woong-Yang ;

Robertson, A. Gordon ;

Laird, Peter W. ;

Henske, Elizabeth P. ;

Kwiatkowski, David J. ;

Park, Peter J. ;

Morgan, Margaret ;

Shuch, Brian ;

Muzny, Donna ;

Wheeler, David A. ;

Linehan, W. Marston ;

Gibbs, Richard A. ;

Rathmell, W. Kimryn ;

Creighton, Chad J. ;

Signoretti, Sabina ;

Seiler, Michael ;

Chao, Hsu ;

Dahdouli, Mike .

CANCER CELL, 2014, 26 (03) :319-330

[10] Sarcomatoid differentiation in renal cell carcinoma - A study of 101 cases [J].

de Peralta-Venturina, M ;

Moch, H ;

Amin, M ;

Tamboli, P ;

Hailemariam, S ;

Mihatsch, M ;

Javidan, J ;

Stricker, H ;

Ro, JY ;

Amin, MB .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (03) :275-284

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