The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

被引：94

作者：

Baccala, R ^{[1
]}

Theofilopoulos, AN ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 01期

关键词：

D O I：

10.1016/j.it.2004.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In lymphopenic conditions, T cells expand to re-establish homeostasis by a process dependent on self-peptide-MHC recognition and the availability of proliferation- and survival-promoting cytokines. Although physiologically normal, chronic recurrence of this process might lead to selection of high-affinity self-reactive T-cell clones and autoimmune disease in susceptible individuals. A recent study in a diabetes-prone mouse model has provided strong evidence to support this hypothesis.

引用

页码：5 / 8

页数：4

共 22 条

[1] Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery [J].

Asavaroengchai, W ;

Kotera, Y ;

Mulé, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :931-936

[2] Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells [J].

Cho, BK ;

Rao, VP ;

Ge, Q ;

Eisen, HN ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) :549-556

[3] ACCELERATION OF THE ONSET OF DIABETES IN NOD MICE BY THYMECTOMY AT WEANING [J].

DARDENNE, M ;

LEPAULT, F ;

BENDELAC, A ;

BACH, JF .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (05) :889-895

[4]

Dudley ME, 2002, SCIENCE, V298, P850, DOI 10.1126/science.1076514

[5] T cell homeostatic proliferation elicits effective antitumor autoimmunity [J].

Dummer, W ;

Niethammer, AG ;

Baccala, R ;

Lawson, BR ;

Wagner, N ;

Reisfeld, RA ;

Theofilopoulos, AN .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (02) :185-192

[6] Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/MHC epitopes and strength of their interaction with T cell receptors [J].

Ge, Q ;

Rao, VP ;

Cho, BK ;

Eisen, HN ;

Chen, JZ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) :1728-1733

[7] Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells? [J].

Grandjean, I ;

Duban, L ;

Bonney, EA ;

Corcuff, E ;

Di Santo, JP ;

Matzinger, P ;

Lantz, O .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (07) :1089-1102

[8]

Hu HM, 2002, CANCER RES, V62, P3914

[9] Maintaining the norm: T-CELL homeostasis [J].

Jameson, SC .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (08) :547-556

[10] A role for TCR affinity in regulating naive T cell homeostasis [J].

Kieper, WC ;

Burghardt, JT ;

Surh, CD .

JOURNAL OF IMMUNOLOGY, 2004, 172 (01) :40-44

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