The present view of the mechanism of protein folding

被引：335
作者：
Daggett, V
Fersht, A
机构：
[1] Univ Washington, Dept Med Chem, Seattle, WA 98195 USA
[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[3] MRC Ctr, Ctr Prot Engn, Cambridge CB2 2QH, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 06期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1126
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.
引用
收藏
页码：497 / 502
页数：7
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