Chemical alterations and regulations of biomolecules in lifestyle-related diseases

被引：6
作者：
Miyoshi, Noriyuki [1 ]
机构：
[1] Univ Shizuoka, Grad Program Food & Nutr Sci, Grad Sch Integrated Pharmaceut & Nutr Sci, Biochem Lab, Shizuoka, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2016年 / 80卷 / 06期
关键词：
lifestyle-related disease; secosterol; isothiocyanate; LC-MS; MEMBRANE-MEDIATED AMYLOIDOGENESIS; OXIDIZED CHOLESTEROL METABOLITES; ISOTHIOCYANATE-INDUCED APOPTOSIS; GT1-7 HYPOTHALAMIC NEURONS; ACTIVATED PROTEIN-KINASES; SINGLET MOLECULAR-OXYGEN; BENZYL ISOTHIOCYANATE; ANTICARCINOGENIC ISOTHIOCYANATES; ATHEROSCLEROTIC ARTERIES; SECOSTEROL ALDEHYDES;
D O I：
10.1080/09168451.2016.1141037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We know experientially that not only nutrient factors but also non-nutritive functional food factors are playing important roles in maintenance of homeostasis, health promotion, and disease prevention. Although some of these effective behaviors are supported by accumulating scientific evidences, it is in general difficult to determine properly in human. Therefore, the discovering of novel biomarker and developments of the analytical method are one of the prudent strategies to understand disease etiology and evaluate efficacies of functional food factors via monitoring the pathophysiological alteration in live body, tissue, and cells. This review describes recent our findings on (1) formation mechanism, bioactivities, quantitative determination of cholesterol ozonolysis product, secosterol as possible biomarker for lifestyle-related disease, and (2) chemical biology approach for the investigating molecular mechanisms of most promising cancer chemopreventive food factors, isothiocyanate-inducing bioactivities.
引用
收藏
页码：1046 / 1053
页数：8
相关论文
共 58 条
  • [1] 7-Ketocholesterol and 5,6-Secosterol Modulate Differently the Stress-Activated Mitogen-Activated Protein Kinases (MAPKs) in Liver Cells
    Anticoli, Simona
    Arciello, Mario
    Mancinetti, Adriano
    De Martinis, Massimo
    Ginaldi, Lia
    Iuliano, Luigi
    Balsano, Clara
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 222 (03) : 586 - 595
  • [2] Investigating antibody-catalyzed ozone generation by human neutrophils
    Babior, BM
    Takeuchi, C
    Ruedi, J
    Gutierrez, A
    Wentworth, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (06) : 3031 - 3034
  • [3] The oxysterol 3β-hydroxy-5-oxo-5,6-secocholestan-6-al changes the phase behavior and structure of phosphatidylethanolamine-phosphatidylcholine mixtures
    Bach, D.
    Epand, R. F.
    Epand, R. M.
    Miller, I. R.
    Wachtel, E.
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2011, 164 (07) : 672 - 679
  • [4] Kinetics of Schiff base formation between the cholesterol ozonolysis product 3β-hydroxy-5-oxo-5,6-secocholestan-6-al and phosphatidylethanolamine
    Bach, D.
    Wachtel, E.
    Miller, I. R.
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2009, 157 (01) : 51 - 55
  • [5] Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation
    Bieschke, J
    Zhang, QH
    Powers, ET
    Lerner, RA
    Kelly, JW
    [J]. BIOCHEMISTRY, 2005, 44 (13) : 4977 - 4983
  • [6] Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization
    Bosco, DA
    Fowler, DM
    Zhang, QH
    Nieva, J
    Powers, ET
    Wentworth, P
    Lerner, RA
    Kelly, JW
    [J]. NATURE CHEMICAL BIOLOGY, 2006, 2 (05) : 249 - 253
  • [7] Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates
    Brown, Kristin K.
    Blaikie, Frances H.
    Smith, Robin A. J.
    Tyndall, Joel D. A.
    Lue, Hongqi
    Bernhagen, Juergen
    Winterbourn, Christine C.
    Hampton, Mark B.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (47) : 32425 - 32433
  • [8] The isothiocyanate class of bioactive nutrients covalently inhibit the MEKKI protein kinase
    Cross, Janet V.
    Foss, Frank W.
    Rady, Joshua M.
    Macdonald, Timothy L.
    Templeton, Dennis J.
    [J]. BMC CANCER, 2007, 7 (1)
  • [9] Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
    Cross, Janet V.
    Rady, Joshua M.
    Foss, Frank W., Jr.
    Lyons, Charles E.
    MacDonald, Timothy L.
    Templeton, Dennis J.
    [J]. BIOCHEMICAL JOURNAL, 2009, 423 : 315 - 321
  • [10] Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat
    Farrar, NS
    Chambers, NJ
    Carlsson, AR
    Denyer, G
    Johnston, GAR
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2001, 28 (5-6) : 386 - 391
123456