Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior

被引：59

作者：

Kleinridders, Andre ^{[1
,2
]}

Pothos, Emmanuel N. ^{[3
,4
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Cent Regulat Metab, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany

[2] German Ctr Diabet Res DZD, Ingolstaedter Land Str 1, D-85764 Neuherberg, Germany

[3] Tufts Univ, Sackler Sch Grad Biomed Sci, Program Pharmacol & Expt Therapeut & Pharmacol &, Sch Med, Boston, MA 02111 USA

[4] Tufts Univ, Dept Immunol, Sch Med, Boston, MA 02111 USA

来源：

CURRENT NUTRITION REPORTS | 2019年 / 8卷 / 02期

关键词：

Diabetes; Obesity; Insulin; Insulin receptor; Dopamine; Mesolimbic pathway; Reward; Food intake; Mood; Depression; Anxiety; Depressive-like behavior;

D O I：

10.1007/s13668-019-0276-z

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose of Review Dietary obesity is primarily attributed to an imbalance between food intake and energy expenditure. Adherence to lifestyle interventions reducing weight is typically low. As a result, obesity becomes a chronic state with increased co-morbidities such as insulin resistance and diabetes. We review the effects of brain insulin action and dopaminergic signal transmission on food intake, reward, and mood as well as potential modulations of these systems to counteract the obesity epidemic. Recent Findings Central insulin and dopamine action are interlinked and impact on food intake, reward, and mood. Brain insulin resistance causes hyperphagia, anxiety, and depressive-like behavior and compromises the dopaminergic system. Such effects can induce reduced compliance to medical treatment. Insulin receptor sensitization and dopamine receptor agonists show attenuation of obesity and improvement of mental health in rodents and humans. Summary Modulating brain insulin and dopamine signaling in obese patients can potentially improve therapeutic outcomes.

引用

页码：83 / 91

页数：9

共 118 条

[1] The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 [J].