Synthesis, crystal structures and antimicrobial activity of dimeric copper(II) complexes with 2-hydroxyphenyl-ethylidene-dithiocarbazates

被引：30

作者：

Lima, Francielle C. ^{[1
]}

Silva, Thayna S. ^{[2
]}

Martins, Carlos H. G. ^{[2
]}

Gatto, Claudia C. ^{[1
]}

机构：

[1] Univ Brasilia IQ UnB, Lab Inorgan Synth & Crystallog, Campus Univ Darcy Ribeiro, BR-70904970 Brasilia, DF, Brazil

[2] Univ Franca, Lab Res Appl Microbiol, BR-14404600 Franca, SP, Brazil

来源：

INORGANICA CHIMICA ACTA | 2018年 / 483卷

基金：

巴西圣保罗研究基金会;

关键词：

Copper(II) complexes; Dithiocarbazate; Crystal structure; Antimicrobial activity; BIDENTATE SCHIFF-BASE; SPECTRAL CHARACTERIZATION; ANTIBACTERIAL ACTIVITY; NICKEL(II) COMPLEX; METAL-COMPLEXES; S-METHYL; DITHIOCARBAZATE; LIGAND; ZN(II); CU(II);

D O I：

10.1016/j.ica.2018.08.032

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The current work reports the synthesis and crystals structure of two copper(II) complexes [(CuL1)(2)] (1) and [(CuL2)(2)] (2), with S-allyl-2-(2 hydroxyphenyl ethylidene)dithiocarbazato and S benzyl 2 (2 hydroxyphenyl-ethylidene) dithiocarbazato (H2L1 and H2L2, respectively). The single-crystal X-ray analyses reveal dimeric structures of the complexes with a distorted square planar coordination geometry. The phenoxo bridging mode observed in these complexes is located between the two copper atoms with ONS-donor ligands. The crystal packings are stabilized by hydrogen bonds involving the adjacent molecules. The compounds were also characterized by physicochemical and spectroscopic methods. The antibacterial and antifungal properties of the free dithiocarbazates and its Cu(II) complexes have been evaluated against several multiresistant bacteria and fungi. In all experiments, a superior antimicrobial activity of the complexes was observed compared to the free ligands.

引用

页码：464 / 472

页数：9

共 40 条

[1] Ali MA, 2001, INORG CHIM ACTA, V320, P1
[2] Mixed-ligand nickel(II) and copper(II) complexes of tridentate ONS and NNS ligands derived from S-alkyldithiocarbazates with the saccharinate ion as a co-ligand
Ali, Mohammad Akbar
Mirza, Aminul Huq
Ting, Wong Yok
Hamid, Malai Haniti S. A.
Bernhardt, Paul V.
Butcher, Ray J.
[J]. POLYHEDRON, 2012, 48 (01) : 167 - 173
[3] Alyea E. C., 1991, STRUCTURAL S BENZYLD, P1625, DOI [10.1016/S0277-5387(00)83773-0, DOI 10.1016/S0277-5387(00)83773-0]
[4] Synthesis, characterization and in vitro anti-amoebic activity of new palladium(II) complexes with 5-nitrothiophene-2-carboxaldehyde N(4)-substituted thiosemicarbazones
Bharti, N
Athar, F
Maurya, MR
Azam, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (17) : 4679 - 4684
[5] Lewis base controlled supramolecular architectures via non-covalent interactions of dioxomolybdenum(VI) complexes with an ONS donor ligand: DFT calculations and biological study
Biswal, Debanjana
Pramanik, Nikhil Ranjan
Chakrabarti, Syamal
Chakraborty, Nirmalya
Acharya, Krishnendu
Mandal, Sudhanshu Sekhar
Ghosh, Saktiprosad
Drew, Michael G. B.
Mondal, Tapan Kumar
Biswas, Sujan
[J]. NEW JOURNAL OF CHEMISTRY, 2015, 39 (04) : 2778 - 2794
[6] Brandsburg K., ESTRUTURAS CRISTAL
[7] C. L. S. I Clinical & Laboratory Standards Institute, 2012, CLSI GUID
[8] Clinical and Laboratory Standards Institute Clinical & Laboratory Standards Institute, 2008, CLSI GUID
[9] Synthesis, Structural and Spectroscopic Characterization of CrIII, FeIII, CoIII, NiII and CuII Complexes with an Asymmetric 1,3,4-Thiadiazole Ligand
Deckert, Christoph
Bittner, Denis
Carrella, Luca M.
Schollmeyer, Dieter
Rentschler, Eva
[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2016, (11) : 1738 - 1747
[10] Targeting copper in cancer therapy: 'Copper That Cancer'
Denoyer, Delphine
Masaldan, Shashank
La Fontaine, Sharon
Cater, Michael A.
[J]. METALLOMICS, 2015, 7 (11) : 1459 - 1476

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