Applying Tobacco Carcinogen and Toxicant Biomarkers in Product Regulation and Cancer Prevention

被引：77

作者：

Hecht, Stephen S. ^{[1
]}

Yuan, Jian-Min ^{[1
]}

Hatsukami, Dorothy ^{[1
]}

机构：

[1] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2010年 / 23卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PROSTAGLANDIN-E METABOLITE; RISK PREDICTION MODEL; LUNG-CANCER; CIGARETTE-SMOKE; ADULT SMOKERS; SHORT-TERM; URINARY; 1-HYDROXYPYRENE; SUSCEPTIBILITY LOCUS; POTENTIAL HARM; OXIDANT STRESS;

D O I：

10.1021/tx100056m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tobacco carcinogen and toxicant biomarkers arc metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.

引用

页码：1001 / 1008

页数：8

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